Magnetization transfer and adiabatic R MRI in the brainstem of Parkinson's disease

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9 Citations (Scopus)

Abstract

Background: In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.

Original languageEnglish (US)
Pages (from-to)623-625
Number of pages3
JournalParkinsonism and Related Disorders
Volume18
Issue number5
DOIs
StatePublished - Jun 1 2012

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Brain Stem
Parkinson Disease
Magnetic Resonance Imaging
Mesencephalon
Pathology

Keywords

  • MRI
  • Magnetization transfer
  • Medulla
  • Parkinson's disease
  • R1ρ

Cite this

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title = "Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease",
abstract = "Background: In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R 1ρ (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.",
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author = "Tuite, {Paul J} and Silvia Mangia and Tyan, {Andrew E.} and Lee, {Michael K} and Michael Garwood and Shalom Michaeli",
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T1 - Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease

AU - Tuite, Paul J

AU - Mangia, Silvia

AU - Tyan, Andrew E.

AU - Lee, Michael K

AU - Garwood, Michael

AU - Michaeli, Shalom

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N2 - Background: In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R 1ρ (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.

AB - Background: In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R 1ρ (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.

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KW - Magnetization transfer

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KW - Parkinson's disease

KW - R1ρ

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