Magnetic resonance studies of brain function and neurochemistry

Kamil Ugurbil, Gregor Adriany, Peter M Andersen, Wei Chen, Rolf Gruetter, Xiaoping Hu, Hellmut Merkle, Dae Shik Kim, Seong Gi Kim, John P Strupp, Xiao-Hong Zhu, Seiji Ogawa

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


In the short time since its introduction, magnetic resonance imaging (MRI) has rapidly evolved to become an indispensable tool for clinical diagnosis and biomedical research. Recently, this methodology has been successfully used for the acquisition of functional, physiological, and biochemical information in intact systems, particularly in the human body. The ability to map areas of altered neuronal activity in the brain, often referred to as functional magnetic resonance imaging (fMRI), is probably one of the most significant recent achievements that rely on this methodology. This development has permitted the examination of functional specialization in human and animal brains with unprecedented spatial resolution, as demonstrated by mapping at the level of orientation and ocular dominance columns in the visual cortex. These functional imaging studies are complemented by the ability to study neurochemistry using magnetic resonance spectroscopy, allowing the determination of metabolic processes that support neurotransmission and neurotransmission rates themselves.

Original languageEnglish (US)
Pages (from-to)633-660
Number of pages28
JournalAnnual Review of Biomedical Engineering
Issue number2000
StatePublished - 2000


  • Bioenergetics
  • Cerebral function
  • Imaging
  • Mapping
  • Neurotransmission
  • Spectroscopy


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