Magnetic Resonance Spectroscopy of the Breast: Current Status

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Invivo magnetic resonance spectroscopy (MRS) of the breast can be used to measure the level of choline-containing compounds, which is a biomarker of malignancy. In the diagnostic setting, MRS can provide high specificity for distinguishing benign from malignant lesions. MRS also can be used as an early response indicator in patients undergoing neoadjuvant chemotherapy. This article describes the acquisition and analysis methods used for measuring total choline levels in the breast using MRS, reviews the findings from clinical studies of diagnosis and treatment response, and discusses problems, limitations, and future developments for this promising clinical technology.

Original languageEnglish (US)
Pages (from-to)625-639
Number of pages15
JournalMagnetic Resonance Imaging Clinics of North America
Volume21
Issue number3
DOIs
StatePublished - Aug 1 2013

Keywords

  • Breast cancer
  • Choline
  • Diagnosis
  • Magnetic resonance spectroscopy
  • Quantification
  • Treatment monitoring

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