Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer

Michael T. Nelson; Lenore I. Everson; Michael Garwood; Tim Emory; Patrick J. Bolan

doi:10.1053/j.sembd.2008.03.004

Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer

Research output: Contribution to journal › Article › peer-review

Abstract

In vivo proton magnetic resonance spectroscopy (¹H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of ¹H MRS measurements of total choline-containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.

Original language	English (US)
Pages (from-to)	100-105
Number of pages	6
Journal	Seminars in Breast Disease
Volume	11
Issue number	2
DOIs	https://doi.org/10.1053/j.sembd.2008.03.004
State	Published - Jun 2008

Bibliographical note

Funding Information:
We would like to acknowledge the following grants from NIH (Grants CA92004, CA120509, RR08079, and RR00400) and the DOD Breast Cancer Research program (DAMD 17-01-1-0331).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

magnetic resonance spectroscopy
spectroscopic imaging
total choline

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10.1053/j.sembd.2008.03.004

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title = "Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer",

abstract = "In vivo proton magnetic resonance spectroscopy (1H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of 1H MRS measurements of total choline-containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.",

keywords = "magnetic resonance spectroscopy, spectroscopic imaging, total choline",

author = "Nelson, \{Michael T.\} and Everson, \{Lenore I.\} and Michael Garwood and Tim Emory and Bolan, \{Patrick J.\}",

note = "Funding Information: We would like to acknowledge the following grants from NIH (Grants CA92004, CA120509, RR08079, and RR00400) and the DOD Breast Cancer Research program (DAMD 17-01-1-0331).",

year = "2008",

month = jun,

doi = "10.1053/j.sembd.2008.03.004",

language = "English (US)",

volume = "11",

pages = "100--105",

journal = "Seminars in Breast Disease",

issn = "1092-4450",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer

AU - Nelson, Michael T.

AU - Everson, Lenore I.

AU - Garwood, Michael

AU - Emory, Tim

AU - Bolan, Patrick J.

N1 - Funding Information: We would like to acknowledge the following grants from NIH (Grants CA92004, CA120509, RR08079, and RR00400) and the DOD Breast Cancer Research program (DAMD 17-01-1-0331).

PY - 2008/6

Y1 - 2008/6

N2 - In vivo proton magnetic resonance spectroscopy (1H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of 1H MRS measurements of total choline-containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.

AB - In vivo proton magnetic resonance spectroscopy (1H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of 1H MRS measurements of total choline-containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.

KW - magnetic resonance spectroscopy

KW - spectroscopic imaging

KW - total choline

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UR - https://www.scopus.com/pages/publications/49049121394#tab=citedBy

U2 - 10.1053/j.sembd.2008.03.004

DO - 10.1053/j.sembd.2008.03.004

M3 - Article

AN - SCOPUS:49049121394

SN - 1092-4450

VL - 11

SP - 100

EP - 105

JO - Seminars in Breast Disease

JF - Seminars in Breast Disease

IS - 2

ER -

Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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