Magnetic Resonance Spectroscopy in the Diagnosis and Treatment of Breast Cancer

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In vivo proton magnetic resonance spectroscopy (1H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of 1H MRS measurements of total choline-containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalSeminars in Breast Disease
Issue number2
StatePublished - Jun 2008

Bibliographical note

Funding Information:
We would like to acknowledge the following grants from NIH (Grants CA92004, CA120509, RR08079, and RR00400) and the DOD Breast Cancer Research program (DAMD 17-01-1-0331).


  • magnetic resonance spectroscopy
  • spectroscopic imaging
  • total choline


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