Magnetic resonance imaging of Alzheimer's disease

Stéphane Lehéricy, Malgorzata Marjanska, Lilia Mesrob, Marie Sarazin, Serge Kinkingnehun

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

A modern challenge for neuroimaging techniques is to contribute to the early diagnosis of neurodegenerative diseases, such as Alzheimer's disease (AD). Early diagnosis includes recognition of pre-demented conditions, such as mild cognitive impairment (MCI) or having a high risk of developing AD. The role of neuroimaging therefore extends beyond its traditional role of excluding other conditions such as neurosurgical lesions. In addition, early diagnosis would allow early treatment using currently available therapies or new therapies in the future. Structural imaging can detect and follow the time course of subtle brain atrophy as a surrogate marker for pathological processes. New MR techniques and image analysis software can detect subtle brain microstructural, perfusion or metabolic changes that provide new tools to study the pathological processes and detect pre-demented conditions. This review focuses on markers of macro- and microstructural, perfusion, diffusion and metabolic MR imaging and spectroscopy in AD.

Original languageEnglish (US)
Pages (from-to)347-362
Number of pages16
JournalEuropean Radiology
Volume17
Issue number2
DOIs
StatePublished - Feb 2007

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Alzheimer's disease
  • Diffusion
  • MRI
  • Perfusion
  • Spectroscopy
  • Volumetry

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