Magnetic particle spectroscopy (MPS) biosensor

Magnetic particle spectroscopy (MPS) is a promising technology for achieving low-cost, point-of-care diagnostics. MPS utilizes the nonlinear magnetization response of magnetic nanoparticles (MNPs) to sinusoidal excitation fields which can be used for a variety of applications, including viscometry, thermometry, and bioassays. In this chapter, we will explore the underlying principles of MPS-based bioassay methodologies. We will discuss how superparamagnetic MNPs enable these implementations, and we will look at the major MPS platform classifications. We will also explore different point-of-care (POC) systems that have been successfully reported for bioassay applications. We will review a representative set of studies utilizing MPS systems for bioassay applications ranging from disease diagnostics to food and water safety. Finally, we will discuss the prospective opportunity landscape and the major challenges to overcome for the MPS technology for successful adoption into the rapidly growing and high-demand market of POC diagnostic implementations.