Magnetic Particle Spectroscopy for Point-of-Care: A Review on Recent Advances

Parsa Yari, Bahareh Rezaei, Clifton Dey, Vinit Kumar Chugh, Naga Venkata Ravi Kumar Veerla, Jian Ping Wang, Kai Wu

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Since its first report in 2006, magnetic particle spectroscopy (MPS)-based biosensors have flourished over the past decade. Currently, MPS are used for a wide range of applications, such as disease diagnosis, foodborne pathogen detection, etc. In this work, different MPS platforms, such as dual-frequency and mono-frequency driving field designs, were reviewed. MPS combined with multi-functional magnetic nanoparticles (MNPs) have been extensively reported as a versatile platform for the detection of a long list of biomarkers. The surface-functionalized MNPs serve as nanoprobes that specifically bind and label target analytes from liquid samples. Herein, an analysis of the theories and mechanisms that underlie different MPS platforms, which enable the implementation of bioassays based on either volume or surface, was carried out. Furthermore, this review draws attention to some significant MPS platform applications in the biomedical and biological fields. In recent years, different kinds of MPS point-of-care (POC) devices have been reported independently by several groups in the world. Due to the high detection sensitivity, simple assay procedures and low cost per run, the MPS POC devices are expected to become more widespread in the future. In addition, the growth of telemedicine and remote monitoring has created a greater demand for POC devices, as patients are able to receive health assessments and obtain results from the comfort of their own homes. At the end of this review, we comment on the opportunities and challenges for POC devices as well as MPS devices regarding the intensely growing demand for rapid, affordable, high-sensitivity and user-friendly devices.

Original languageEnglish (US)
Article number4411
Issue number9
StatePublished - May 2023

Bibliographical note

Funding Information:
This study was financially supported by the Texas Tech University through HEF New Faculty Startup, NRUF Start Up and Core Research Support Fund. This study was also financially supported by the U.S. Department of Agriculture—National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. R.B. acknowledges the Distinguished Graduate Student Assistantships (DGSA) offered by Texas Tech University. V.K.C. acknowledges the Interdisciplinary Doctoral Fellowship (IDF) offered by University of Minnesota.

Publisher Copyright:
© 2023 by the authors.


  • biosensor
  • disease detection
  • food safety
  • magnetic particle spectroscopy
  • point-of-care
  • surface-based assay
  • volumetric assay

PubMed: MeSH publication types

  • Journal Article
  • Review


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