Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications

Vinit Kumar Chugh, Kai Wu, Abilash Nair, Arturo di Girolamo, James Schealler, Hoang Vuong, Will Davies, Adam Wall, Emmet Whitely, Renata Saha, Diqing Su, Jian Ping Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.

Original languageEnglish (US)
Title of host publicationFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791883549
DOIs
StatePublished - 2020
Event2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States
Duration: Apr 6 2020Apr 9 2020

Publication series

NameFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020

Conference

Conference2020 Design of Medical Devices Conference, DMD 2020
CountryUnited States
CityMinneapolis
Period4/6/204/9/20

Bibliographical note

Funding Information:
The authors thank former team members contributing to the development of this MPS system, which can be found at: https://magicoil.ece.umn.edu. This study was financially supported by the University of Minnesota through the UROP program, the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program.

Keywords

  • Handheld device
  • Harmonics
  • Magnetic nanoparticle
  • Magnetic particle spectroscopy

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