Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications

Vinit K Chugh; Kai Wu; Abilash Nair; Arturo di Girolamo; James Schealler; Hoang Vuong; Will Davies; Adam Wall; Emmet Whitely; Renata Saha; Diqing Su; Jian Ping Wang

doi:10.1115/DMD2020-9054

Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications

Vinit K Chugh, Kai Wu, Abilash Nair, Arturo di Girolamo, James Schealler, Hoang Vuong, Will Davies, Adam Wall, Emmet Whitely, Renata Saha, Diqing Su, Jian Ping Wang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.

Original language	English (US)
Title of host publication	Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020
Publisher	American Society of Mechanical Engineers (ASME)
ISBN (Electronic)	9780791883549
DOIs	https://doi.org/10.1115/DMD2020-9054
State	Published - 2020
Event	2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States Duration: Apr 6 2020 → Apr 9 2020

Publication series

Name	Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020

Conference

Conference	2020 Design of Medical Devices Conference, DMD 2020
Country/Territory	United States
City	Minneapolis
Period	4/6/20 → 4/9/20

Bibliographical note

Funding Information:
The authors thank former team members contributing to the development of this MPS system, which can be found at: https://magicoil.ece.umn.edu. This study was financially supported by the University of Minnesota through the UROP program, the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program.

Publisher Copyright:
Copyright © 2020 ASME

Keywords

Handheld device
Harmonics
Magnetic nanoparticle
Magnetic particle spectroscopy

Publisher link

10.1115/DMD2020-9054

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Chugh, V. K., Wu, K., Nair, A., di Girolamo, A., Schealler, J., Vuong, H., Davies, W., Wall, A., Whitely, E., Saha, R., Su, D., & Wang, J. P. (2020). Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications. In Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020 (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DMD2020-9054

Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications. / Chugh, Vinit K; Wu, Kai; Nair, Abilash et al.
Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chugh, VK, Wu, K, Nair, A, di Girolamo, A, Schealler, J, Vuong, H, Davies, W, Wall, A, Whitely, E, Saha, R, Su, D & Wang, JP 2020, Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications. in Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020, American Society of Mechanical Engineers (ASME), 2020 Design of Medical Devices Conference, DMD 2020, Minneapolis, United States, 4/6/20. https://doi.org/10.1115/DMD2020-9054

Chugh VK, Wu K, Nair A, di Girolamo A, Schealler J, Vuong H et al. Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications. In Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME). 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020). doi: 10.1115/DMD2020-9054

Chugh, Vinit K ; Wu, Kai ; Nair, Abilash et al. / Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications. Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

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abstract = "In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.",

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AU - Schealler, James

AU - Vuong, Hoang

AU - Davies, Will

AU - Wall, Adam

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AU - Saha, Renata

AU - Su, Diqing

AU - Wang, Jian Ping

N1 - Funding Information: The authors thank former team members contributing to the development of this MPS system, which can be found at: https://magicoil.ece.umn.edu. This study was financially supported by the University of Minnesota through the UROP program, the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. Publisher Copyright: Copyright © 2020 ASME

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AB - In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.

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Magnetic particle spectroscopy-based handheld device for wash-free, easy-to-use, and solution-phase immunoassay applications

Abstract

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Conference

Bibliographical note

Keywords

Publisher link

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