In recent years, magnetic particle spectroscopy (MPS) has emerged as a new technology for immunoassay applications. In MPS, alternating magnetic fields are applied to magnetic nanoparticles (MNPs). The magnetic responses of these nanoparticles are collected and recorded by a pair of specially designed pick-up coils. These magnetic responses contain higher harmonics that are specific to the physical changes of the nanoparticles such as the binding events of target analytes to nanoparticles. This volumetric-based bioassay method analyses the response signal from the whole nanoparticle suspension, thus, allows one step and wash-free immunoassay with minimum technical requirements. In this work, we developed a handheld MPS system as a future highly sensitive, cheap, in vitro, and easy-to-use point-of-care (POC) detection kit.
|Original language||English (US)|
|Title of host publication||Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020|
|Publisher||American Society of Mechanical Engineers (ASME)|
|State||Published - 2020|
|Event||2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States|
Duration: Apr 6 2020 → Apr 9 2020
|Name||Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020|
|Conference||2020 Design of Medical Devices Conference, DMD 2020|
|Period||4/6/20 → 4/9/20|
Bibliographical noteFunding Information:
The authors thank former team members contributing to the development of this MPS system, which can be found at: https://magicoil.ece.umn.edu. This study was financially supported by the University of Minnesota through the UROP program, the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program.
- Handheld device
- Magnetic nanoparticle
- Magnetic particle spectroscopy