Magnetic nanoparticles and magnetic particle spectroscopy-based bioassays: A 15 year recap

Kai Wu, Jinming Liu, Vinit K Chugh, Shuang Liang, Renata Saha, Venkatramana Divana Krishna Bhat, Maxim C.J. Cheeran, Jianping Wang

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Magnetic nanoparticles (MNPs) have unique physical and chemical properties, such as high surface area to volume ratio and size-related magnetism, which are completely different from their bulk materials. Benefiting from the facile synthesis and chemical modification strategies, MNPs have been widely studied for applications in nanomedicine. Herein, we firstly summarized the designs of MNPs from the perspectives of materials and physicochemical properties tailored for biomedical applications. Magnetic particle spectroscopy (MPS), first reported in 2006, has flourished as an independent platform for many biological and biomedical applications. It has been extensively reported as a versatile platform for a variety of bioassays along with the artificially designed MNPs, where the MNPs serve as magnetic nanoprobes to specifically probe target analytes from fluid samples. In this review, the mechanisms and theories of different MPS platforms realizing volumetric- and surface-based bioassays are discussed. Some representative works of MPS platforms for applications such as disease diagnosis, food safety and plant pathology monitoring, drug screening, thrombus maturity assessments are reviewed. At the end of this review, we commented on the rapid growth and booming of MPS-based bioassays in its first 15 years. We also prospected opportunities and challenges that portable MPS devices face in the rapidly growing demand for fast, inexpensive, and easy-to-use biometric techniques.

Original languageEnglish (US)
Article number022001
JournalNano Futures
Issue number2
StatePublished - Jun 1 2022

Bibliographical note

Funding Information:
This study was financially supported by the Institute of Engineering in Medicine, the Robert F Hartmann Endowed Chair professorship, the University of Minnesota Medical School, and the University of Minnesota Physicians and Fairview Health Services through COVID-19 Rapid Response Grant. This study was also financially supported by the US Department of Agriculture—National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. Research reported in this publication was supported by the National Institute Of Dental and Craniofacial Research of the National Institutes of Health under Award Number R42DE030832. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2022 IOP Publishing Ltd.


  • bioassay
  • disease diagnosis
  • food safety
  • magnetic nanoparticle
  • magnetic particle spectroscopy
  • point-of-care

PubMed: MeSH publication types

  • Journal Article


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