Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models

Qun Zhao, Luning Wang, Rui Cheng, Leidong Mao, Robert D. Arnold, Elizabeth W. Howerth, Zhuo G. Chen, Simon Platt

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40°C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalTheranostics
Volume2
Issue number1
DOIs
StatePublished - 2012

Keywords

  • Head and neck cancer
  • Hyperthermia
  • Magnetic nanoparticles
  • Mouse

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