Abstract
Multilayered gold/nickel 'barcode' nanowires were grown using electrodeposition for multiplexed detection in biomolecular assays. Non-specific uptake of barcoded nanowires by osteosarcoma cells (OSCA-8) was observed by scanning and transmission electron microscopy images. Barcode-tagged cells were manipulated with an external magnetic field and were readily separated from untagged cells. Separation efficiency increased from a maximum of 30.14% to a maximum of 47.9% as clustering was reduced. Cells exposed to nanowires (both those that incorporated wires and those that did not) appeared to be viable suggesting that the nanowires are not toxic.
| Original language | English (US) |
|---|---|
| Article number | 6392423 |
| Pages (from-to) | 453-456 |
| Number of pages | 4 |
| Journal | IEEE Transactions on Magnetics |
| Volume | 49 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
Keywords
- Cell manipulation
- cellular uptake
- magnetic carriers
- magnetic separation
- nanowires
