Magnesium, oxidative stress, inflammation, and cardiovascular disease

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Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms by which Mg deficiency plays detrimental roles in cardiovascular diseases and review the results of clinical trials of Mg supplementation for heart failure, arrhythmias and other cardiovascular diseases.

Original languageEnglish (US)
Article number907
Pages (from-to)1-31
Number of pages31
Issue number10
StatePublished - Oct 2020

Bibliographical note

Funding Information:
The work was supported by R01 HL104025 (S.C.D.J.), HL106592 (S.C.D.J.), and University of Minnesota 2019 ODAT Translational Grant (M.L.) from NIH National Center for Advancing Translational Science UL1TR002494.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antioxidant
  • Arrhythmias
  • Heart failure with preserved ejection fraction
  • Heart failure with reduced ejection fraction
  • Inflammation
  • Mitochondria


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