Macroscopic and microscopic measurement of myocardial infarct size - A Comparison

N. Banka, I. S. Anand, O. P. Nirankari, S. Gulati, P. L. Sharma, R. N. Chakravarti, P. L. Wahi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Infarct size measured by microscopic method is consistently larger than that measured macroscopically, indicating that certain areas of infarction are missed when observed macroscopically. Existence of a good correlation between the two methods, however, suggests that macroscopic estimation of infarct size would be enough for initial screening of the interventions designed for salvation of ischemic myocardium, as it is an easy method. An additional advantage of this method is that it can be utilized to measure infarct size as early as 72 h after production of infarction. Comparison of weight and volume method of macroscopic estimation of infarct size has shown that they do not give significantly different results. Weight method being less cumbersome and less time-consuming, may be adopted for initial screening of cardioprotective agents.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalResearch in Experimental Medicine
Volume181
Issue number2
DOIs
StatePublished - Jun 1 1982

Keywords

  • Measurement of infarct size
  • Monkey
  • Myocardial infarction

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