Abstract
Macrophage migration inhibition factor (MIF), a soluble mediator of delayed hypersensitivity, was assayed for in the aqueous humor of rabbits undergoing corneal graft rejection. Penetrating and interlamellar xenografts and interlamellar allografts were performed in rabbits, and aqueous humor was obtained during the rejection. Significant levels of MIF activity were measured in the aqueous humor early in the course of xenograft and allograft rejection, and MIF activity was present during the course of the active rejection. This activity returned to near normal after the active rejection resolved. No significant MIF activity could be measured during the nonspecific inflammations produced by alkali burns, multiple paracenteses, intracorneal clove oil, or mechanical debriding of the endothelium.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 858-865 |
| Number of pages | 8 |
| Journal | American journal of ophthalmology |
| Volume | 82 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1976 |
Bibliographical note
Funding Information:From the Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis, Minnesota, and the National Institutes of Health, Bethesda, Maryland. This study was supported in part by grants from the Minnesota Medical Foundation, and National Institutes of Health grants EY-0027 and EY-01211.