Macrophage dependent lymphocyte immunostimulation in cattle infected with Mycobacterium bovis and with Mycobacterium avium

Charles C Muscoplat, C. O. Thoen, A. W. Chen, D. W. Johnson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cultures of bovine peripheral blood leukocytes were prepared from calves inoculated with Mycobacterium bovis and with M. avium. Suitable lymphocyte stimulation was obtained with specific and nonspecific mycobacterial mitogens. Leukocyte cultures depleted of adherent, macrophage type cells did not respond to stimulation with purified protein derivative, although they were responsive to phytohemagglutinin.

Original languageEnglish (US)
Pages (from-to)675-677
Number of pages3
JournalInfection and immunity
Volume10
DOIs
StatePublished - 1974

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