Macromolecular imaging agents containing lanthanides: Can conceptual promise lead to clinical potential?

Keyphrases

• Lanthanides 100%
• Gd(III) 100%
• Clinical Potential 100%
• Imaging Agents 100%
• Small Molecules 66%
• Chelates 66%
• Image Resolution 66%
• Polymer Complex 66%
• Noncovalent Complexes 66%
• Dendrimer Complexes 66%
• Macromolecules 33%
• Pharmacokinetics 33%
• Three-dimensional (3D) 33%
• Non-covalent 33%
• Clinical Development 33%
• Contrast Enhancement 33%
• Large Molecules 33%
• Contrast Agent 33%
• Gadolinium 33%
• Magnetic Resonance Imaging Contrast Agents 33%
• Chelation 33%
• Biodistribution 33%
• Serum Albumin 33%
• Relaxivity 33%
• Multimeric 33%
• Diagnostic Applications 33%
• Water Protons 33%
• Macromolecular Structure 33%
• Diagnostic Agents 33%
• Image Contrast 33%
• Bound Water 33%
• Resolution Enhancement 33%
• Aggregation-resistant 33%
• Water Proton Relaxivity 33%
• Blood Pool Imaging 33%
• Macromolecular Association 33%
• FDA Approval 33%
• T1 Contrast Agents 33%
• Non-invasive Diagnostic Methods 33%

Chemistry

• Contrast Medium 100%
• Lanthanoid Atom 100%
• chelate 100%
• Dendrimer 100%
• Rare Earth Element 100%
• Pharmacokinetics 50%
• Gadolinium 50%
• Pool 50%
• Chelation 50%
• Macromolecular Structure 50%
• Diagnostic Agent 50%
• Nuclear Magnetic Resonance Imaging Agent 50%
• T1 Contrast 50%
• Macromolecule 50%
• Albumin 50%
• Hydrophile 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Dendrimer 100%
• Contrast Medium 100%
• Lanthanide 100%
• Gadolinium 50%
• Gadofosveset 50%
• Hydrophile 50%
• Nuclear Magnetic Resonance Imaging Agent 50%
• Biodistribution 50%
• Chelate 50%
• Diagnostic Agent 50%
• Serum Albumin 50%
• Pharmacokinetics 50%