Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: A total synthesis of (-)-dactylolide [and zampanolide]

Keyphrases

• Total Synthesis 100%
• Ti(IV) 100%
• Macrolactonization 100%
• Dactylolide 100%
• Zampanolide 100%
• Epoxy Acid 100%
• Carboxylic Acids 50%
• In Situ 50%
• Epoxides 50%
• Proton 50%
• Dienes 50%
• Primary Amides 50%
• Intermolecular Modes 50%
• 1,2-Diols 50%
• Carbinolamide 50%
• Oxoammonium 50%
• Vic-diol 50%
• Ring-closing Metathesis 50%
• Selective Oxidation 50%
• Allylic Alcohols 50%
• Aldol Reaction 50%

Chemistry

• Diol 100%
• Macrolactonization 100%
• Carboxylic Acid 50%
• Epoxide 50%
• Primary Amide 50%
• Aluminum 50%
• Metathesis Reaction 50%
• Allylic Alcohol 50%
• Selective Oxidation 50%
• Ring Closing Metathesis 50%
• Aldol Reaction 50%