Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: A total synthesis of (-)-dactylolide [and zampanolide]

Chemistry

• Macrolactonization 100%
• Diol 100%
• Primary Amide 50%
• Aluminum 50%
• Metathesis Reaction 50%
• Allylic Alcohol 50%
• Selective Oxidation 50%
• Ring Closing Metathesis 50%
• Aldol Reaction 50%
• Epoxide 50%
• Carboxylic Acid 50%

Keyphrases

• 1,2-diols 50%