Lysosomal Ca²⁺ flux modulates automaticity in ventricular cardiomyocytes and correlates with arrhythmic risk

Keyphrases

• Automaticity 100%
• Ca2+ Flux 100%
• Arrhythmic Risk 100%
• Ventricular Cardiomyocytes 100%
• Lysosomal Ca2+ 100%
• Induced Pluripotent Stem Cells (iPSCs) 30%
• Ventricular Tachycardia 20%
• Ventricular Arrhythmia 20%
• Ca2+ Release 20%
• Lysosome 20%
• Ca2+ Handling 20%
• Engineered Heart Tissue 20%
• TRPML1 20%
• Cell Membrane 10%
• Myocardial Ischemia 10%
• Ca2+ 10%
• Mitochondria 10%
• Cardiomyocytes 10%
• Spontaneous Activity 10%
• Sarcoplasmic Reticulum 10%
• Infarcted 10%
• Channel Antagonist 10%
• Two-channel 10%
• Clinical Strategies 10%
• Ca2+ Cycling 10%
• Transient Receptor Potential 10%
• Human Induced Pluripotent Stem Cell-derived Cardiomyocytes (hiPSC-CMs) 10%
• Mucolipin 10%
• Transcription Factor EB 10%
• Abnormal Automaticity 10%

Biochemistry, Genetics and Molecular Biology

• Cardiac Muscle Cell 100%
• Human Induced Pluripotent Stem Cell 100%
• Lysosome 50%
• Cardiac Dysrhythmia 50%
• Ventricular Tachycardia 50%
• Mitochondrion 25%
• Cell Membrane 25%
• Transcription Factors 25%
• Receptor Potential 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Calcium Ion 100%
• Heart Ventricle Arrhythmia 22%
• Heart Ventricle Tachycardia 22%
• Receptor 11%
• Heart Muscle Ischemia 11%
• Transcription Factors 11%