TY - JOUR
T1 - Lymphoplasmacytic lymphoma and a CD5+ lymphoproliferative process presenting as composite disease in the bone marrow
T2 - a report of two cases
AU - Girton, Mark
AU - Grzywacz, Bartosz
AU - Foster, Laahn
AU - Fan, Jinbo
AU - Courville, Elizabeth L.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2021/1/2
Y1 - 2021/1/2
N2 - Correct subclassification of B cell lymphoma requires integration of histologic and immunohistochemical findings in addition to results of flow cytometric immunophenotyping, cytogenetic analysis, and molecular studies. Evaluation for the MYD88 L265P mutation and immunohistochemical staining for LEF1 can be helpful in the workup of small B cell lymphomas. In this case report of two diagnostically difficult cases, we present two patients with lymphoplasmacytic lymphoma (LPL) and a CD5+ lymphoproliferative process presenting as composite disease within the bone marrow. In both cases, integration of ancillary studies and results of biopsy at other sites of disease in addition to a careful histologic review and an expanded immunohistochemistry panel were important for the correct final classification.
AB - Correct subclassification of B cell lymphoma requires integration of histologic and immunohistochemical findings in addition to results of flow cytometric immunophenotyping, cytogenetic analysis, and molecular studies. Evaluation for the MYD88 L265P mutation and immunohistochemical staining for LEF1 can be helpful in the workup of small B cell lymphomas. In this case report of two diagnostically difficult cases, we present two patients with lymphoplasmacytic lymphoma (LPL) and a CD5+ lymphoproliferative process presenting as composite disease within the bone marrow. In both cases, integration of ancillary studies and results of biopsy at other sites of disease in addition to a careful histologic review and an expanded immunohistochemistry panel were important for the correct final classification.
KW - Chronic lymphocytic leukemia
KW - Composite
KW - Lymphoplasmacytic lymphoma
KW - Small lymphocytic lymphoma
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U2 - 10.1007/s12308-020-00437-1
DO - 10.1007/s12308-020-00437-1
M3 - Article
AN - SCOPUS:85098524052
SN - 1868-9256
VL - 14
SP - 61
EP - 68
JO - Journal of Hematopathology
JF - Journal of Hematopathology
IS - 1
ER -
