Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions

Joyce L. Sanchez, Peter W. Hunt, Cavan S. Reilly, Hiroyu Hatano, Gregory J. Beilman, Alexander Khoruts, Jake S. Jasurda, Ma Somsouk, Ann Thorkelson, Samuel Russ, Jodi Anderson, Steven G. Deeks, Timothy W. Schacker

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Human immunodeficiency virus (HIV) replication causes lymphoid tissue (LT) fibrosis, which causes CD4 + T-cell depletion. It is unknown whether people who spontaneously control HIV replication have LT fibrosis. We measured LT fibrosis and CD4 + T cells in 25 HIV controllers, 10 noncontrollers, 45 HIV-positive individuals receiving therapy, and 10 HIV-negative individuals. Controllers had significant LT fibrosis and CD4 + T-cell depletion, similar to noncontrollers, but the so-called Berlin patient (in whom HIV infection was cured) had near normal LT. Thus, LT fibrosis occurs in all HIV-infected subjects, and current therapy does not reverse it. Reversal of fibrosis during a curative intervention suggests that ongoing low-level virus production may maintain LT fibrosis.

Original languageEnglish (US)
Pages (from-to)1068-1075
Number of pages8
JournalJournal of Infectious Diseases
Volume211
Issue number7
DOIs
StatePublished - Apr 1 2015

Keywords

  • HIV
  • HIV controllers
  • fibrosis

Fingerprint Dive into the research topics of 'Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions'. Together they form a unique fingerprint.

  • Cite this