Abstract
Primary hypoadrenocorticism, or Addison’s disease, is an autoimmune condition common in certain dog breeds that leads to the destruction of the adrenal cortex and a clinical syndrome involving anorexia, gastrointestinal upset, and electrolyte imbalances. Previous studies have demonstrated that this destruction is strongly associated with lymphocytic-plasmacytic inflammation and that the lymphocytes are primarily T cells. In this study, we used both immunohistochemistry and in situ hybridization to characterize the T-cell subtypes involved. We collected postmortem specimens of 5 dogs with primary hypoadrenocorticism and 2 control dogs and, using the aforementioned techniques, showed that the lymphocytes are primarily CD4+ rather than CD8+. These findings have important implications for improving our understanding of the pathogenesis and in searching for the underlying causative genetic polymorphisms.
Original language | English (US) |
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Pages (from-to) | 177-181 |
Number of pages | 5 |
Journal | Veterinary pathology |
Volume | 55 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2018 |
Bibliographical note
Funding Information:The author(s) received the following financial support for the research, authorship, and/or publication of this article: This study was funded in part by a National Institutes of Health T32 training award provided to SGF (5T32OD11130-07). Additional funding was provided by the American Kennel Club Canine Health Foundation and the Poodle Club of America Foundation.
Publisher Copyright:
© 2016, © The Author(s) 2016.
Keywords
- Addison’s disease
- adrenal gland
- dogs
- endocrine diseases
- hypoadrenocorticism
- immunophenotype
- lymphocyte subsets