Lymphocyte subpopulations and immunodeficiency in calves with acute lymphocytic leukemia

C. C. Muscoplat; D. W. Johnson; K. A. Pomeroy; J. M. Olson; V. L. Larson; J. B. Stevens; D. K. Sorensen

Lymphocyte subpopulations and immunodeficiency in calves with acute lymphocytic leukemia

C. C. Muscoplat, D. W. Johnson, K. A. Pomeroy, J. M. Olson, V. L. Larson, J. B. Stevens, D. K. Sorensen

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Abstract

The frequency of surface immunoglobulin (SIg), a B lymphocyte marker, was studied on peripheral blood lymphocytes (PBL) obtained from 2 calves with acute lymphocytic leukemia (ALL). Approximately 19% of PBL from normal age matched calves demonstrated SIg, and these were classified as B lymphocytes, whereas less than 1% of the PBL from calves affected with ALL had SIg and these were classified as B lymphocytes. The mitogenic activity of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) was studied on PBL from normal calves and cows and from the 2 calves with ALL. Lymphocytes from the 2 calves with ALL were unresponsive to PHA and PWM, as indicated by the degree of stimulation. The value of these findings and possible explanations are discussed.

Original language	English (US)
Pages (from-to)	1571-1573
Number of pages	3
Journal	American journal of veterinary research
Volume	35
Issue number	12
State	Published - 1974

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title = "Lymphocyte subpopulations and immunodeficiency in calves with acute lymphocytic leukemia",

abstract = "The frequency of surface immunoglobulin (SIg), a B lymphocyte marker, was studied on peripheral blood lymphocytes (PBL) obtained from 2 calves with acute lymphocytic leukemia (ALL). Approximately 19% of PBL from normal age matched calves demonstrated SIg, and these were classified as B lymphocytes, whereas less than 1% of the PBL from calves affected with ALL had SIg and these were classified as B lymphocytes. The mitogenic activity of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) was studied on PBL from normal calves and cows and from the 2 calves with ALL. Lymphocytes from the 2 calves with ALL were unresponsive to PHA and PWM, as indicated by the degree of stimulation. The value of these findings and possible explanations are discussed.",

author = "Muscoplat, {C. C.} and Johnson, {D. W.} and Pomeroy, {K. A.} and Olson, {J. M.} and Larson, {V. L.} and Stevens, {J. B.} and Sorensen, {D. K.}",

year = "1974",

language = "English (US)",

volume = "35",

pages = "1571--1573",

journal = "American journal of veterinary research",

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TY - JOUR

T1 - Lymphocyte subpopulations and immunodeficiency in calves with acute lymphocytic leukemia

AU - Muscoplat, C. C.

AU - Johnson, D. W.

AU - Pomeroy, K. A.

AU - Olson, J. M.

AU - Larson, V. L.

AU - Stevens, J. B.

AU - Sorensen, D. K.

PY - 1974

Y1 - 1974

N2 - The frequency of surface immunoglobulin (SIg), a B lymphocyte marker, was studied on peripheral blood lymphocytes (PBL) obtained from 2 calves with acute lymphocytic leukemia (ALL). Approximately 19% of PBL from normal age matched calves demonstrated SIg, and these were classified as B lymphocytes, whereas less than 1% of the PBL from calves affected with ALL had SIg and these were classified as B lymphocytes. The mitogenic activity of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) was studied on PBL from normal calves and cows and from the 2 calves with ALL. Lymphocytes from the 2 calves with ALL were unresponsive to PHA and PWM, as indicated by the degree of stimulation. The value of these findings and possible explanations are discussed.

AB - The frequency of surface immunoglobulin (SIg), a B lymphocyte marker, was studied on peripheral blood lymphocytes (PBL) obtained from 2 calves with acute lymphocytic leukemia (ALL). Approximately 19% of PBL from normal age matched calves demonstrated SIg, and these were classified as B lymphocytes, whereas less than 1% of the PBL from calves affected with ALL had SIg and these were classified as B lymphocytes. The mitogenic activity of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) was studied on PBL from normal calves and cows and from the 2 calves with ALL. Lymphocytes from the 2 calves with ALL were unresponsive to PHA and PWM, as indicated by the degree of stimulation. The value of these findings and possible explanations are discussed.

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AN - SCOPUS:0016152586

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JO - American journal of veterinary research

JF - American journal of veterinary research

IS - 12

ER -

Lymphocyte subpopulations and immunodeficiency in calves with acute lymphocytic leukemia

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