Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors

Keith Henry, Alejo Erice, Henry H. Balfour, Max Schmeling, Jessica Berthiaume, Ken Wallace

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Mitochondrial toxicity was evaluated in peripheral lymphocytes obtained from a cohort of 10 subjects with extensive exposure to nucleoside reverse transcriptase inhibitors (NRTI) and matched controls. Mitochondrial copy number was expressed as the ratio of mitochondrial (cytochrome b)-to-nuclear (pyruvate kinase) genes as measured by real-time polymerase chain reaction. There was no significant difference between the mtDNA: nuclear DNA ratios for the NRTI-treated subjects (mean ratio 187.2) versus the matched controls (mean ratio 199).

Original languageEnglish (US)
Pages (from-to)2485-2487
Number of pages3
JournalAIDS
Volume16
Issue number18
DOIs
StatePublished - Dec 6 2002

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