Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors

Keith Henry; Alejo Erice; Henry H. Balfour; Max Schmeling; Jessica Berthiaume; Ken Wallace

doi:10.1097/00002030-200212060-00018

Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors

Keith Henry, Alejo Erice, Henry H. Balfour, Max Schmeling, Jessica Berthiaume, Ken Wallace

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Mitochondrial toxicity was evaluated in peripheral lymphocytes obtained from a cohort of 10 subjects with extensive exposure to nucleoside reverse transcriptase inhibitors (NRTI) and matched controls. Mitochondrial copy number was expressed as the ratio of mitochondrial (cytochrome b)-to-nuclear (pyruvate kinase) genes as measured by real-time polymerase chain reaction. There was no significant difference between the mtDNA: nuclear DNA ratios for the NRTI-treated subjects (mean ratio 187.2) versus the matched controls (mean ratio 199).

Original language	English (US)
Pages (from-to)	2485-2487
Number of pages	3
Journal	AIDS
Volume	16
Issue number	18
DOIs	https://doi.org/10.1097/00002030-200212060-00018
State	Published - Dec 6 2002

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title = "Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors",

abstract = "Mitochondrial toxicity was evaluated in peripheral lymphocytes obtained from a cohort of 10 subjects with extensive exposure to nucleoside reverse transcriptase inhibitors (NRTI) and matched controls. Mitochondrial copy number was expressed as the ratio of mitochondrial (cytochrome b)-to-nuclear (pyruvate kinase) genes as measured by real-time polymerase chain reaction. There was no significant difference between the mtDNA: nuclear DNA ratios for the NRTI-treated subjects (mean ratio 187.2) versus the matched controls (mean ratio 199).",

author = "Keith Henry and Alejo Erice and Balfour, {Henry H.} and Max Schmeling and Jessica Berthiaume and Ken Wallace",

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T1 - Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors

AU - Henry, Keith

AU - Erice, Alejo

AU - Balfour, Henry H.

AU - Schmeling, Max

AU - Berthiaume, Jessica

AU - Wallace, Ken

PY - 2002/12/6

Y1 - 2002/12/6

N2 - Mitochondrial toxicity was evaluated in peripheral lymphocytes obtained from a cohort of 10 subjects with extensive exposure to nucleoside reverse transcriptase inhibitors (NRTI) and matched controls. Mitochondrial copy number was expressed as the ratio of mitochondrial (cytochrome b)-to-nuclear (pyruvate kinase) genes as measured by real-time polymerase chain reaction. There was no significant difference between the mtDNA: nuclear DNA ratios for the NRTI-treated subjects (mean ratio 187.2) versus the matched controls (mean ratio 199).

AB - Mitochondrial toxicity was evaluated in peripheral lymphocytes obtained from a cohort of 10 subjects with extensive exposure to nucleoside reverse transcriptase inhibitors (NRTI) and matched controls. Mitochondrial copy number was expressed as the ratio of mitochondrial (cytochrome b)-to-nuclear (pyruvate kinase) genes as measured by real-time polymerase chain reaction. There was no significant difference between the mtDNA: nuclear DNA ratios for the NRTI-treated subjects (mean ratio 187.2) versus the matched controls (mean ratio 199).

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SN - 0269-9370

VL - 16

SP - 2485

EP - 2487

JO - AIDS

JF - AIDS

IS - 18

ER -

Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors

Abstract

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