Adhesion of lymphocytes to endothelium is vital to lymphocyte migration into lymphoid tissue and into inflammatory sites. In this review, Yoji Shimizu and colleagues identify the molecules that mediate lymphocyte-endothelial cell adhesion, describe the underlying principles of lymphocyte migration, and discuss a model of the sequence of events that allow a lymphocyte to successfully attach to endothelium and migrate into the surrounding tissue.
Bibliographical noteFunding Information:
We apologize that proper acknowledgment <)f all of the contributions made by investigators in this field was not possible. Yoli Shimizu i~ supported by NIH grant AI31126, and an American Cancer Society Junior Faculty Research Award.