Lymphocyte infiltration, expression of interleukin (IL) -1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours

J. H. Kim, C. H. Yu, Ji Young Yhee, KeumSoon Im, J. H. Sur

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Malignant tumours are often associated with a relatively high number of tumour-infiltrating lymphocytes (TILs) and associated local cytokine production and these factors are thought to play a role in tumour progression. These aspects of tumour microenvironment have not been studied in canine mammary gland tumours (MGTs). The present study investigates TILs and the presence of related cytokines, as well as the expression of breast cancer susceptibility gene-1 (BRCA1), in canine MGTs. Immunohistochemistry, immunoblotting and reverse transcriptase-polymerase chain reaction were performed to evaluate these parameters. Three times as many T lymphocytes as B cells infiltrated canine MGTs. A correlation was found between expression of interleukin (IL)-1 and IL-6 and metastasis. There was an association between the expression of TILs, cytokines and mutation of BRCA1, suggesting that all of these factors may play a role in tumour progression.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalJournal of Comparative Pathology
Volume142
Issue number2-3
DOIs
StatePublished - Feb 2010
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank Ms R. H Jang for excellent technical assistance and private veterinary clinics for providing access to samples of canine MGTs. This study was supported by a grant from the Konkuk University Research Foundation 2009. This report summarizes work contained within a thesis submitted by J. H. Kim to fulfil the requirements for a PhD.

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