Lymphocyte aging in allophenic mice

Carol M. Warner, Carol J. Briggs, Terry E. Meyer, Donna J. Spannaus, Han Yi Yang, Doris Balinsky

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Allophenic mice are chimeras which are produced from the aggregation of two genotypically distinct embryos. In this study, embryos from the C57BL/6J and A/J strains were used to produce C57BL/6J ↔ A/J allophenic mice. These strains were chosen because of their markedly different lifespans, their different glucose phosphate isomerase (GPI) isozymes, and their different H-2 haplotypes [C57BL/6J: long-lived, Gpi-1b, H-2b; A/J: short-lived, Gpi-1a, H-2a. The mice were bled at two month intervals and the composition of their peripheral blood lymphocytes determined at each point from analysis of GPI isozymes and H-2 antigens. It was founr that the proportion of long-lived (C57BL/6J) lymphocytes tended to increase with age. Moreover, the total lifespan of the allophenic mice was directly related to the percentage of long-lived lymphocytes in their peripheral blood.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalExperimental Gerontology
Volume20
Issue number1
DOIs
StatePublished - 1985

Bibliographical note

Funding Information:
work was supported by NIH grant AG-02440.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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