Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncologic Patients

Can Özütemiz; Luke A. Krystosek; An L. Church; Anil Chauhan; Jutta M. Ellermann; Evidio Domingo-Musibay; Daniel Steinberger

doi:10.1148/radiol.2021210275

Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncologic Patients

Can Özütemiz, Luke A. Krystosek, An L. Church, Anil Chauhan, Jutta M. Ellermann, Evidio Domingo-Musibay, Daniel Steinberger

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Abstract

Five cases of axillary lymphadenopathy are presented, which occurred after COVID-19 vaccination and mimicked metastasis in a vulnerable oncologic patient group. Initial radiologic diagnosis raised concerns for metastasis. However, further investigation revealed that patients received COVID-19 vaccinations in the ipsilateral arm prior to imaging. In two cases, lymph node biopsy results confirmed vaccination-related reactive lymphadenopathy. Ipsilateral axillary swelling or lymphadenopathy was reported based on symptoms and physical examination in COVID-19 vaccine trials. Knowledge of the potential for COVID-19 vaccine–related ipsilateral adenopathy is necessary to avoid unnecessary biopsy and change in therapy.

Original language	English (US)
Pages (from-to)	E290-E294
Journal	Radiology
Volume	300
Issue number	1
Early online date	Feb 24 2021
DOIs	https://doi.org/10.1148/radiol.2021210275 https://doi.org/10.1148/radiol.2021210275
State	Published - Jul 2021

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© RSNA, 2021

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title = "Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncologic Patients",

abstract = "Five cases of axillary lymphadenopathy are presented, which occurred after COVID-19 vaccination and mimicked metastasis in a vulnerable oncologic patient group. Initial radiologic diagnosis raised concerns for metastasis. However, further investigation revealed that patients received COVID-19 vaccinations in the ipsilateral arm prior to imaging. In two cases, lymph node biopsy results confirmed vaccination-related reactive lymphadenopathy. Ipsilateral axillary swelling or lymphadenopathy was reported based on symptoms and physical examination in COVID-19 vaccine trials. Knowledge of the potential for COVID-19 vaccine–related ipsilateral adenopathy is necessary to avoid unnecessary biopsy and change in therapy.",

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AU - Özütemiz, Can

AU - Krystosek, Luke A.

AU - Church, An L.

AU - Chauhan, Anil

AU - Ellermann, Jutta M.

AU - Domingo-Musibay, Evidio

AU - Steinberger, Daniel

PY - 2021/7

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N2 - Five cases of axillary lymphadenopathy are presented, which occurred after COVID-19 vaccination and mimicked metastasis in a vulnerable oncologic patient group. Initial radiologic diagnosis raised concerns for metastasis. However, further investigation revealed that patients received COVID-19 vaccinations in the ipsilateral arm prior to imaging. In two cases, lymph node biopsy results confirmed vaccination-related reactive lymphadenopathy. Ipsilateral axillary swelling or lymphadenopathy was reported based on symptoms and physical examination in COVID-19 vaccine trials. Knowledge of the potential for COVID-19 vaccine–related ipsilateral adenopathy is necessary to avoid unnecessary biopsy and change in therapy.

AB - Five cases of axillary lymphadenopathy are presented, which occurred after COVID-19 vaccination and mimicked metastasis in a vulnerable oncologic patient group. Initial radiologic diagnosis raised concerns for metastasis. However, further investigation revealed that patients received COVID-19 vaccinations in the ipsilateral arm prior to imaging. In two cases, lymph node biopsy results confirmed vaccination-related reactive lymphadenopathy. Ipsilateral axillary swelling or lymphadenopathy was reported based on symptoms and physical examination in COVID-19 vaccine trials. Knowledge of the potential for COVID-19 vaccine–related ipsilateral adenopathy is necessary to avoid unnecessary biopsy and change in therapy.

UR - https://doi.org/10.1148/radiol.2021210275

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DO - 10.1148/radiol.2021210275

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IS - 1

ER -

Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncologic Patients

Abstract

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