Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncologic Patients

Can Özütemiz, Luke A. Krystosek, An L. Church, Anil Chauhan, Jutta M. Ellermann, Evidio Domingo-Musibay, Daniel Steinberger

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Five cases of axillary lymphadenopathy are presented, which occurred after COVID-19 vaccination and mimicked metastasis in a vulnerable oncologic patient group. Initial radiologic diagnosis raised concerns for metastasis. However, further investigation revealed that patients received COVID-19 vaccinations in the ipsilateral arm prior to imaging. In two cases, lymph node biopsy results confirmed vaccination-related reactive lymphadenopathy. Ipsilateral axillary swelling or lymphadenopathy was reported based on symptoms and physical examination in COVID-19 vaccine trials. Knowledge of the potential for COVID-19 vaccine–related ipsilateral adenopathy is necessary to avoid unnecessary biopsy and change in therapy.

Original languageEnglish (US)
Pages (from-to)E290-E294
Issue number1
Early online dateFeb 24 2021
StatePublished - Jul 2021

Bibliographical note

Publisher Copyright:
© RSNA, 2021

PubMed: MeSH publication types

  • Journal Article
  • Case Reports


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