Lung transplantation for pulmonary sarcoidosis. Twenty-five years of experience in the USA

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Lung transplantation is the ultimate treatment for end-stage pulmonary sarcoidosis. Post-transplant survival outcomes remain unclear. Methods: Survival models were used to assess survival and graft outcomes in patients with sarcoid among 20 896 lung transplants performed in the USA. Results: 695 lung recipients were transplanted for pulmonary sarcoidosis. Sarcoid lung recipients had similar median survival rate (69.7 months (IQR 60.2-79.3)) compared with the nonsarcoid lung recipients (63.1 months (IQR 61.4-64.8), p=0.88). In multivariate Cox regression, sarcoidosis was not independently associated with worse mortality (HR 0.96 (95% CI 0.85 to 1.08), p=0.51). Among the sarcoid lung recipients, double lung transplantation (HR 0.76 (0.58 to 0.99), p=0.04) and lung allocation score era (HR 0.74 (0.56 to 0.97), p=0.03) were associated with improved survival. Conclusions: Recipients of lung transplants for pulmonary sarcoidosis had similar outcomes compared with nonsarcoid lung recipients.

Original languageEnglish (US)
Pages (from-to)378-379
Number of pages2
JournalThorax
Volume71
Issue number4
DOIs
StatePublished - Apr 1 2016

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Pulmonary Sarcoidosis
Lung Transplantation
Lung
Transplants
Survival
Graft Survival
Sarcoidosis
Survival Rate
Mortality

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Lung transplantation for pulmonary sarcoidosis. Twenty-five years of experience in the USA. / Taimeh, Ziad A; Hertz, Marshall I; Shumway, Sara J; Pritzker, Marc R.

In: Thorax, Vol. 71, No. 4, 01.04.2016, p. 378-379.

Research output: Contribution to journalArticle

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AU - Shumway, Sara J

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N2 - Objective: Lung transplantation is the ultimate treatment for end-stage pulmonary sarcoidosis. Post-transplant survival outcomes remain unclear. Methods: Survival models were used to assess survival and graft outcomes in patients with sarcoid among 20 896 lung transplants performed in the USA. Results: 695 lung recipients were transplanted for pulmonary sarcoidosis. Sarcoid lung recipients had similar median survival rate (69.7 months (IQR 60.2-79.3)) compared with the nonsarcoid lung recipients (63.1 months (IQR 61.4-64.8), p=0.88). In multivariate Cox regression, sarcoidosis was not independently associated with worse mortality (HR 0.96 (95% CI 0.85 to 1.08), p=0.51). Among the sarcoid lung recipients, double lung transplantation (HR 0.76 (0.58 to 0.99), p=0.04) and lung allocation score era (HR 0.74 (0.56 to 0.97), p=0.03) were associated with improved survival. Conclusions: Recipients of lung transplants for pulmonary sarcoidosis had similar outcomes compared with nonsarcoid lung recipients.

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