Luminescent Lanthanide Probes for Inorganic and Organic Phosphates

Thibaut L.M. Martinon, Valérie C. Pierre

Research output: Contribution to journalReview articlepeer-review

Abstract

Inorganic and organic phosphates-including orthophosphate, nucleotides, and DNA-are some of the most fundamental anions in cellular biology, regulating numerous processes of both medical and environmental significance. The characteristic long lifetimes of emitting lanthanides, including the brighter europium(III) and terbium(III), make them ideally suited for the development of molecular probes for the detection of phosphates directly in complex aqueous media. Moreover, given their high oxophilicity and the exquisite sensitivity of their quantum yields to their hydration number, those luminescent lanthanides are perfect for the detection of phosphates. Herein we discuss the principles that have guided the recent developments of molecular probes selective for inorganic or organic phosphates and how these lanthanide complexes facilitate the study of numerous biological processes.

Original languageEnglish (US)
Article numbere202200495
JournalChemistry - An Asian Journal
Volume17
Issue number16
DOIs
StatePublished - Aug 15 2022

Bibliographical note

Funding Information:
The authors thank the support of the National Institutes of Health provided by R01 DK124333‐01A1 and National Science Foundation provided by CHE‐ 2203624.

Publisher Copyright:
© 2022 The Authors. Chemistry – An Asian Journal published by Wiley-VCH GmbH.

Keywords

  • ATP
  • DNA
  • lanthanide
  • luminescent
  • phosphate

PubMed: MeSH publication types

  • Journal Article
  • Review

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