Lower motor neuron disease in a patient with auto-antibodies against gal(β l-3) galNAc in gangliosides GM1 and GD1b: Improvement following immunotherapy

M. E. Shy, T. Heiman-Patterson, G. J. Parry, A. Tahmoush, V. A. Evans, P. K. Schick

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Abstract

We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (β 1-3)GalNAc.

Original languageEnglish (US)
Pages (from-to)842-844
Number of pages3
JournalNeurology
Volume40
Issue number5
DOIs
StatePublished - May 1990

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