Lower motor neuron disease in a patient with auto-antibodies against gal(β l-3) galNAc in gangliosides GM1 and GD1b: Improvement following immunotherapy

M. E. Shy; T. Heiman-Patterson; G. J. Parry; A. Tahmoush; V. A. Evans; P. K. Schick

doi:10.1212/wnl.40.5.842

Lower motor neuron disease in a patient with auto-antibodies against gal(β l-3) galNAc in gangliosides GM₁ and GD_1b: Improvement following immunotherapy

M. E. Shy, T. Heiman-Patterson, G. J. Parry, A. Tahmoush, V. A. Evans, P. K. Schick

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Abstract

We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM₁ detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD_1b and Gal (β 1-3)GalNAc.

Original language	English (US)
Pages (from-to)	842-844
Number of pages	3
Journal	Neurology
Volume	40
Issue number	5
DOIs	https://doi.org/10.1212/wnl.40.5.842
State	Published - May 1990
Externally published	Yes

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title = "Lower motor neuron disease in a patient with auto-antibodies against gal(β l-3) galNAc in gangliosides GM1 and GD1b: Improvement following immunotherapy",

abstract = "We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (β 1-3)GalNAc.",

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AU - Shy, M. E.

AU - Heiman-Patterson, T.

AU - Parry, G. J.

AU - Tahmoush, A.

AU - Evans, V. A.

AU - Schick, P. K.

PY - 1990/5

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N2 - We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (β 1-3)GalNAc.

AB - We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (β 1-3)GalNAc.

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Lower motor neuron disease in a patient with auto-antibodies against gal(β l-3) galNAc in gangliosides GM₁ and GD_1b: Improvement following immunotherapy

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