TY - JOUR
T1 - Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's
AU - Buijsse, Brian
AU - Lee, Duk Hee
AU - Steffen, Lyn M
AU - Erickson, Richard R.
AU - Luepker, Russell V
AU - Jacobs Jr, David R
AU - Holtzman, Jordan L.
PY - 2012/6/15
Y1 - 2012/6/15
N2 - Background: Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality. Methods: We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4). Results: OR's for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006). The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002). Conclusions: Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.
AB - Background: Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality. Methods: We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4). Results: OR's for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006). The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002). Conclusions: Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.
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U2 - 10.1371/journal.pone.0038901
DO - 10.1371/journal.pone.0038901
M3 - Article
C2 - 22719980
AN - SCOPUS:84862488588
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 6
M1 - e38901
ER -