Low serum albumin. Association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness

Aaron R. Folsom, Jing Ma, John H. Eckfeldt, F. Javier Nieto, Patricia A. Metcalf, Ralph W. Barnes, Atherosclerosis Risk in Communities (ARIC) Study Investigators The Atherosclerosis Risk in Communities (ARIC) Study Investigators

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50 Scopus citations

Abstract

We examined the association of serum albumin concentration with diabetes mellitus and other cardiovascular risk factors, prevalent cardiovascular disease, and ultrasonographically assessed carotid artery intima-media thickness using data from 45- to 64-year-old adults in the Atherosclerosis Risk in Communities (ARIC) Study. The mean albumin concentration was 0.04 to 0.12 g/L lower in participants with diabetes and 0.02 to 0.06 g/L lower in those with cardiovascular disease, compared to participants without these conditions. However, lower serum albumin level was also correlated with most traditional risk factors and hemostatic variables. On adjustment for these, there was essentially no association between serum albumin and prevalent cardiovascular disease. Likewise, there was no association between albumin and carotid intima-media thickness (a marker of atherosclerosis). While hypoalbuminemia may be a marker for chronic disease and perhaps renal loss of albumin, it seems unlikely that it is an important cause of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalAnnals of epidemiology
Volume5
Issue number3
DOIs
StatePublished - May 1995

Bibliographical note

Funding Information:
This work was supported by contracts NOl-HC-55015, NOI-HC-55016, NOl-HC-55018, NOl-HC-55019, NOl-HC-55020, NOI-HC-55021, and NOl-HC-55022 from the US National Heart, Lung, and Blood Institute. The authors thank the following ARIC staff for their important contributions: Catherine Paton, Jeannette Bensen, Delilah Posey, and Amy Haire at University of North Carolina, Chapel Hill; Connie I. Myers, Virginia L. Overman, Stephanie A. Parker, and Liza B. Sullivan at University of Mississippi Medical Center, Jackson; Laura Kemmis, John O’Brien, Linda Goldman, and Barbara Kuehl at University of Minnesota, Minneapolis; Sunny Harrell, Carole Shearer, Pam Grove, and Mary Ann Cocodrilli at The Johns Hopkins University, Baltimore; Valarie Stinson, Pam Pfile, Hoang Pham, and Teri Trevino at University of Texas Medical School, Houston; Wanda Wright, Karima Ghazzaly, Sandra Sanders, and Charles Etta Rhodes at The Methodist Hospital, Houston; Regina DeLacy, Delilah Cook, Carolyn Bell, Teresa Crotts, and Suzanne Pillsbury at Bowman-Gray School of Medicine, Winston-Salem; and Ernestine Bland, Hope Bryan, Myra Carpenter, and Carry Croghan at University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill.

Keywords

  • Albumin
  • atherosclerosis
  • cardiovascular disease
  • diabetes mellitus

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