Low prevalence of diabetes distress following total pancreatectomy with islet autotransplantation

Audrey Lane, James S Hodges, Peggy Ptacek, K. Louise Berry, Gregory J Beilman, Ty B Dunn, Timothy L Pruett, Srinath Chinnakotla, Barbara R Kuzmak, Melena D Bellin

Research output: Contribution to journalArticle

Abstract

Diabetes distress (DD), or psychological fatigue associated with diabetes management, is common in type 1 and 2 diabetes mellitus and is associated with poor glycemic control. Diabetes distress has never been evaluated in patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for chronic pancreatitis. We analyzed DD after TPIAT in 260 patients (average age 34.3 [standard deviation 15], 75.5% F) undergoing TPIAT between 2006 and 2014. Each patient completed 1 or more diabetes distress scale (DDS) questionnaires from 1 to 7 years post-TPIAT (631 total). We examined changes in DD over 7 years and also patient characteristics associated with DD 1 year post-TPIAT (n = 189). One year after TPIAT, 151 of 189 (80%) reported no or low distress (DD<2). Diabetes distress increased over time by an average of 0.084 (SE 0.017) points per year, an average 0.59 point increase from years 1 to 7 (P <.0001). Insulin-dependent patients had significantly greater DD 1 year post-TPIAT compared to insulin-independent patients (P <.0001). Higher DD was associated with poorer glycemic control as indicated by HbA1c (P <.0001). Prevalence of DD is low but increases over time after TPIAT. Insulin dependence and poorer glycemic control are associated with higher levels of DD.

Original languageEnglish (US)
Article numbere13237
JournalClinical Transplantation
Volume32
Issue number5
DOIs
StatePublished - May 1 2018

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Pancreatectomy
Autologous Transplantation
Autografts
Insulin
Chronic Pancreatitis
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Fatigue
Psychology

Keywords

  • autoislet transplant
  • chronic pancreatitis
  • diabetes
  • diabetes distress
  • pancreatectomy

PubMed: MeSH publication types

  • Journal Article

Cite this

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title = "Low prevalence of diabetes distress following total pancreatectomy with islet autotransplantation",
abstract = "Diabetes distress (DD), or psychological fatigue associated with diabetes management, is common in type 1 and 2 diabetes mellitus and is associated with poor glycemic control. Diabetes distress has never been evaluated in patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for chronic pancreatitis. We analyzed DD after TPIAT in 260 patients (average age 34.3 [standard deviation 15], 75.5{\%} F) undergoing TPIAT between 2006 and 2014. Each patient completed 1 or more diabetes distress scale (DDS) questionnaires from 1 to 7 years post-TPIAT (631 total). We examined changes in DD over 7 years and also patient characteristics associated with DD 1 year post-TPIAT (n = 189). One year after TPIAT, 151 of 189 (80{\%}) reported no or low distress (DD<2). Diabetes distress increased over time by an average of 0.084 (SE 0.017) points per year, an average 0.59 point increase from years 1 to 7 (P <.0001). Insulin-dependent patients had significantly greater DD 1 year post-TPIAT compared to insulin-independent patients (P <.0001). Higher DD was associated with poorer glycemic control as indicated by HbA1c (P <.0001). Prevalence of DD is low but increases over time after TPIAT. Insulin dependence and poorer glycemic control are associated with higher levels of DD.",
keywords = "autoislet transplant, chronic pancreatitis, diabetes, diabetes distress, pancreatectomy",
author = "Audrey Lane and Hodges, {James S} and Peggy Ptacek and {Louise Berry}, K. and Beilman, {Gregory J} and Dunn, {Ty B} and Pruett, {Timothy L} and Srinath Chinnakotla and Kuzmak, {Barbara R} and Bellin, {Melena D}",
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T1 - Low prevalence of diabetes distress following total pancreatectomy with islet autotransplantation

AU - Lane, Audrey

AU - Hodges, James S

AU - Ptacek, Peggy

AU - Louise Berry, K.

AU - Beilman, Gregory J

AU - Dunn, Ty B

AU - Pruett, Timothy L

AU - Chinnakotla, Srinath

AU - Kuzmak, Barbara R

AU - Bellin, Melena D

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