Low-dose sultamicillin versus amoxicillin-clavulanic acid in the treatment of acute bacterial sinusitis in adults: A randomized clinical trial

Mehrdad Hasibi, Minoo Mohraz, Mahboubeh Haji-Abdolbaghi, Mehrnaz Rasoolinejad, Armin Rashidi, Mehdi Abouzari

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Several pathogens implicated in acute bacterial sinusitis have developed a notable incidence of antibiotic resistance usually through the production of a beta-lactamase. The purpose of this study was to compare the effectiveness of amoxicillin-clavulanic acid with that of low-dose sultamicillin in the treatment of acute bacterial sinusitis. Patients with acute sinusitis were randomly allocated in either of 2 groups: patients in group A (n = 21) received 625 mg amoxicillin-clavulanic acid 3 times daily for 10 days, and group B (n = 23) received 375 mg oral sultamicillin 2 times daily for the same duration. The 2 groups were not statistically different regarding age and sex. In group A, both intention-to-treat and per-protocol cure rates were 85.7%, whereas the corresponding figures in group B were 82.6% and 86.4%, respectively. Cure rates were not statistically different between the 2 groups, and side effects in group B were not significantly more common than in group A. In conclusion, low-dose sultamicillin can be considered as an effective and safe therapeutic regimen for acute bacterial sinusitis.

Original languageEnglish (US)
Pages (from-to)104-105
Number of pages2
JournalInfectious Diseases in Clinical Practice
Volume15
Issue number2
DOIs
StatePublished - Mar 2007

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