Several pathogens implicated in acute bacterial sinusitis have developed a notable incidence of antibiotic resistance usually through the production of a beta-lactamase. The purpose of this study was to compare the effectiveness of amoxicillin-clavulanic acid with that of low-dose sultamicillin in the treatment of acute bacterial sinusitis. Patients with acute sinusitis were randomly allocated in either of 2 groups: patients in group A (n = 21) received 625 mg amoxicillin-clavulanic acid 3 times daily for 10 days, and group B (n = 23) received 375 mg oral sultamicillin 2 times daily for the same duration. The 2 groups were not statistically different regarding age and sex. In group A, both intention-to-treat and per-protocol cure rates were 85.7%, whereas the corresponding figures in group B were 82.6% and 86.4%, respectively. Cure rates were not statistically different between the 2 groups, and side effects in group B were not significantly more common than in group A. In conclusion, low-dose sultamicillin can be considered as an effective and safe therapeutic regimen for acute bacterial sinusitis.
|Original language||English (US)|
|Number of pages||2|
|Journal||Infectious Diseases in Clinical Practice|
|State||Published - Mar 2007|