Low-dose aspirin for primary prevention of cardiovascular disease: Trends in use patterns among African American adults in Minnesota, 2015–2019

Jeremy R. Van't Hof, Sue Duval, Niki C. Oldenburg, Jeffrey R. Misialek, Milton Mickey Eder, Clarence Jones, John R. Finnegan, Russell V. Luepker

Research output: Contribution to journalArticlepeer-review


Cardiovascular disease (CVD) disproportionately affects African Americans. Aspirin has long been recommended to reduce cardiovascular events. However, national guideline changes in 2016 limited the aspirin recommended population and several clinical trials questioning the utility of primary prevention aspirin were published in 2018. In light of the recent guidelines and study findings, we investigated primary prevention aspirin use among urban African American adults. Using three cross-sectional surveys, we collected data from self-identified African Americans with no CVD in 2015, 2017 and 2019, querying information on CVD risk factors, health behaviors and beliefs, and aspirin use. Poisson regression modeling was used to estimate age- and risk-factor adjusted aspirin prevalence, trends and associations. A total of 1491 African Americans adults, ages 45–79, were included in this analysis; 61% were women. There was no change in age- and risk factor-adjusted aspirin use over the 3 surveys for women (37%, 34% and 35% respectively) or men (27%, 25%, 30% respectively). However, fewer participants believed aspirin was helpful in 2019 compared to 2015—75% versus 84% (p < 0.001). Aspirin discussions with a health care practitioner were highly associated with aspirin use (adjusted RR 2.97, 95% CI 2.49–3.54) and aspirin use was 2.56 times higher (adjusted RR 95% CI 2.17–3.03) in respondents who agreed that people close to them thought they should take aspirin compared with those who disagreed or did not know. Despite major changes in national guidelines, overall primary prevention aspirin use did not significantly change in these African American samples from 2015 to 2019.

Original languageEnglish (US)
Article number106589
JournalPreventive medicine
StatePublished - Jul 1 2021

Bibliographical note

Funding Information:
This work was supported by a grant from the National Heart, Lung, and Blood Institute, National Institutes of Health, United States : R01HL126041 .

Publisher Copyright:
© 2021 Elsevier Inc.


  • Aspirin
  • Guideline
  • Primary prevention
  • Trends

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural


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