Low-Affinity Platelet Factor 4 ¹H NMR Derived Aggregate Equilibria Indicate a Physiologic Preference for Monomers over Dimers and Tetramers

Keyphrases

• Physiologic 100%
• Low Affinity 100%
• 1H nuclear Magnetic Resonance (1H NMR) 100%
• Platelet Factor 4 100%
• Platelets 11%
• Proton 11%
• Specificity Protein 1 11%
• Ionic Strength 11%
• Minimum Value 11%
• Monomer-dimer 11%
• Low Ionic Strength 11%
• Resonance Integral 11%
• Biological Activity 5%
• Glycosaminoglycans 5%
• PH Dependence 5%
• Biologically Active 5%
• Binding Affinity 5%
• Heparin 5%
• Electrostatic Interaction 5%
• Side Chain 5%
• Sodium Chloride 5%
• Nuclear Magnetic Resonance 5%
• Heparin Binding 5%
• Equilibrium Constant 5%
• Slow Exchange 5%
• Repulsion 5%
• Quaternary Structure 5%
• Active State 5%
• Aggregation Properties 5%
• Structural Matrix 5%
• Binding Mechanism 5%
• Chemotactic Agent 5%
• Proton nuclear Magnetic Resonance 5%
• Solvent Conditions 5%
• Physiologic Conditions 5%
• Aggregate State 5%
• Equilibrium Association Constant 5%
• Tetramer Formation 5%
• Like-charge 5%

Biochemistry, Genetics and Molecular Biology

• Platelet Factor 4 100%
• Ionic Strength 23%
• Heparin 11%
• Platelet 11%
• Biochemistry 5%
• Static Electricity 5%
• Protein Quaternary Structure 5%
• Proton Nuclear Magnetic Resonance 5%
• Binding Affinity 5%
• Equilibrium Constant 5%
• Glycosaminoglycan 5%
• Arginine 5%
• Biological Activity 5%