Lost in translation

applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Tunneling nanotubes (TNTs) are membranous conduits for direct cell-to-cell communication. Until the past decade, little had been known about their composite structure, function, and mechanisms of action in both normal physiologic conditions as well as in disease states. Now TNTs are attracting increasing interest for their key role(s) in the pathogenesis of disease, including neurodegenerative disorders, inflammatory and infectious diseases, and cancer. The field of TNT biology is still in its infancy, but inroads have been made in determining potential mechanisms and function of these remarkable structures. For example, TNTs function as critical conduits for cellular exchange of information; thus, in cancer, they may play an important role in critical pathophysiologic features of the disease, including cellular invasion, metastasis, and emergence of chemotherapy drug resistance. Although the TNT field is still in a nascent stage, we propose that TNTs can be investigated as novel targets for drug-based treatment of cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalFEBS Journal
Volume284
Issue number5
DOIs
StatePublished - Mar 1 2017

Fingerprint

Nanotubes
Cell culture
Cell Culture Techniques
Communication
Neurodegenerative Diseases
Neurodegenerative diseases
Neoplasms
Chemotherapy
Composite structures
Drug Resistance
Cell Communication
Pharmaceutical Preparations
Communicable Diseases
Neoplasm Metastasis
Drug Therapy

Keywords

  • 3D cell biology
  • 3D confocal imaging
  • in vivo imaging
  • intercellular communication
  • intercellular transfer
  • membrane tubes
  • tunneling nanotubes

Cite this

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title = "Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments",
abstract = "Tunneling nanotubes (TNTs) are membranous conduits for direct cell-to-cell communication. Until the past decade, little had been known about their composite structure, function, and mechanisms of action in both normal physiologic conditions as well as in disease states. Now TNTs are attracting increasing interest for their key role(s) in the pathogenesis of disease, including neurodegenerative disorders, inflammatory and infectious diseases, and cancer. The field of TNT biology is still in its infancy, but inroads have been made in determining potential mechanisms and function of these remarkable structures. For example, TNTs function as critical conduits for cellular exchange of information; thus, in cancer, they may play an important role in critical pathophysiologic features of the disease, including cellular invasion, metastasis, and emergence of chemotherapy drug resistance. Although the TNT field is still in a nascent stage, we propose that TNTs can be investigated as novel targets for drug-based treatment of cancer and other diseases.",
keywords = "3D cell biology, 3D confocal imaging, in vivo imaging, intercellular communication, intercellular transfer, membrane tubes, tunneling nanotubes",
author = "Emil Lou and Patrick O'Hare and Subree Subramanian and Steer, {Clifford J}",
year = "2017",
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T2 - applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments

AU - Lou, Emil

AU - O'Hare, Patrick

AU - Subramanian, Subree

AU - Steer, Clifford J

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Tunneling nanotubes (TNTs) are membranous conduits for direct cell-to-cell communication. Until the past decade, little had been known about their composite structure, function, and mechanisms of action in both normal physiologic conditions as well as in disease states. Now TNTs are attracting increasing interest for their key role(s) in the pathogenesis of disease, including neurodegenerative disorders, inflammatory and infectious diseases, and cancer. The field of TNT biology is still in its infancy, but inroads have been made in determining potential mechanisms and function of these remarkable structures. For example, TNTs function as critical conduits for cellular exchange of information; thus, in cancer, they may play an important role in critical pathophysiologic features of the disease, including cellular invasion, metastasis, and emergence of chemotherapy drug resistance. Although the TNT field is still in a nascent stage, we propose that TNTs can be investigated as novel targets for drug-based treatment of cancer and other diseases.

AB - Tunneling nanotubes (TNTs) are membranous conduits for direct cell-to-cell communication. Until the past decade, little had been known about their composite structure, function, and mechanisms of action in both normal physiologic conditions as well as in disease states. Now TNTs are attracting increasing interest for their key role(s) in the pathogenesis of disease, including neurodegenerative disorders, inflammatory and infectious diseases, and cancer. The field of TNT biology is still in its infancy, but inroads have been made in determining potential mechanisms and function of these remarkable structures. For example, TNTs function as critical conduits for cellular exchange of information; thus, in cancer, they may play an important role in critical pathophysiologic features of the disease, including cellular invasion, metastasis, and emergence of chemotherapy drug resistance. Although the TNT field is still in a nascent stage, we propose that TNTs can be investigated as novel targets for drug-based treatment of cancer and other diseases.

KW - 3D cell biology

KW - 3D confocal imaging

KW - in vivo imaging

KW - intercellular communication

KW - intercellular transfer

KW - membrane tubes

KW - tunneling nanotubes

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