Loss of parvalbumin in the hippocampus of MAM schizophrenia model rats is attenuated by peripubertal diazepam

Yijuan Du, Anthony A. Grace

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Loss of parvalbumin interneurons in the hippocampus is a robust finding in schizophrenia brains. Rats exposed during embryonic day 17 to methylazoxymethanol acetate exhibit characteristics consistent with an animal model of schizophrenia, including decreased parvalbumin interneurons in the ventral hippocampus. We reported previously that peripubertal administration of diazepam prevented the emergence of pathophysiology in adult methylazoxymethanol acetate rats. Methods: We used an unbiased stereological method to examine the impact of peripubertal diazepam treatment on parvalbumin interneuron number in the ventral subiculum, dentate gyrus of the hippocampus and the basolateral amygdala. Results: Methylazoxymethanol acetate rats with peripubertal diazepam showed significantly more parvalbumin interneurons (3355 ± 173 in the ventral subiculum, 1211 ± 76 in the dentate gyrus) than methylazoxymethanol acetate without diazepam (2375 ± 109 and 824 ± 54, respectively). No change was found in the basolateral amygdala. Conclusions: Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats.

Original languageEnglish (US)
JournalInternational Journal of Neuropsychopharmacology
Volume19
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Bibliographical note

Funding Information:
This work was funded by National Institute of Mental Health, MH57440 (A.A.G.). We thank Dr. Susan Sesack for helpful discussion and Niki MacMurdo for technical support.

Publisher Copyright:
© The Author 2016. Published by Oxford University Press on behalf of CINP.

Keywords

  • Animal model
  • Diazepam
  • Parvalbumin interneuron
  • Schizophrenia

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