Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5

Keyphrases

• Morphine Dependence 100%
• Morphine Reward 100%
• GRK5 100%
• G Protein-coupled Receptor Kinase 5 100%
• Morphine 80%
• μ-opioid Receptor 80%
• Knock-in Mouse Model 80%
• Opioids 60%
• Receptor Phosphorylation 60%
• GRK3 60%
• Threonine 40%
• Addiction 40%
• Opioid Drugs 40%
• Conditioned Place Preference 40%
• G Protein-coupled Receptor Kinase 40%
• Fentanyl 20%
• Cocaine 20%
• Phosphorylation 20%
• Phosphate 20%
• Antinociceptive 20%
• Clinical Benefit 20%
• Wild Mice 20%
• Morphine Tolerance 20%
• In Vivo Phosphorylation 20%
• Physical Dependence 20%
• Conditioned Place Preference Test 20%
• Carboxyl 20%
• In Vivo Evidence 20%
• Acceptor Site 20%
• Antinociception 20%
• Liquid Chromatography-tandem Mass Spectrometry Analysis 20%
• Opioid Dependence 20%
• Hot Plate 20%
• Reward Effects 20%
• Analgesic Properties 20%
• Kinase Isoform 20%
• Nanoflow Liquid Chromatography 20%
• Selective Phosphorylation 20%
• Co-immunoprecipitation (co-IP) 20%
• Etazene 20%

Neuroscience

• Morphine 100%
• G Protein Coupled Receptor Kinase 5 100%
• GRK5 83%
• μ-Opioid Receptor 66%
• In Vivo 50%
• Receptor Phosphorylation 50%
• Conditioned Place Preference 50%
• Threonine 33%
• G Protein-Coupled Receptor Kinase 33%
• Serine 33%
• Behavior (Neuroscience) 16%
• Binding Site 16%
• C-Terminus 16%
• Fentanyl 16%
• Opioid Dependence 16%
• Agonist 16%
• Immunoprecipitation 16%
• Duragesic 16%
• Liquid Chromatography-Mass Spectrometry 16%