Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin

Xiaomin Bao, Huai Deng, Jørgen Johansen, Jack Girton, Kristen M. Johansen

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1Su(var)3-1[3] allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.

Original languageEnglish (US)
Pages (from-to)1355-1358
Number of pages4
JournalGenetics
Volume176
Issue number2
DOIs
StatePublished - Jun 2007

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