Look out heme, Mac is back in town

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In this issue of Blood, Kovtunovych et al report the curative effect of a nonmyeloablative bone marrow transplant for anemia and organ dysfunction in heme oxygenase 1 (HO-1)-deficient mice by restoring the ability to detoxify heme through the repopulation of the tissues with wild-type macrophages.1 These findings provide the basis for new therapies for this lethal disorder in children lacking the HO-1 gene (Hmox1).

Original languageEnglish (US)
Pages (from-to)1388-1389
Number of pages2
Issue number9
StatePublished - Aug 28 2014
Externally publishedYes


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