Longitudinal study of serum antibody responses to retinal antigens in acute ocular toxoplasmosis

I. Willard Abrahams, Dale S. Gregerson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We conducted a longitudinal study of five patients with anterior and posterior acute toxoplasmic uveitis to determine the relationships, if any, between the level of toxoplasmic activity, therapy, and serum antibody titers to retinal proteins. All patients showed increased serum antibody responses to S-, P-, or p59ag-antigen isolated from bovine retina. The titers to S-antigen tended to decrease with clinical improvement and stabilized at titers somewhat higher than normal; the anti-p59ag titers decreased in those patients treated with clindamycin and sulfadiazine and remained increased in the one untreated patient in this series. The anti-P titers increased throughout the acute attack and remained increased even after the attack ended.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalAmerican journal of ophthalmology
Issue number2
StatePublished - Feb 1982

Bibliographical note

Funding Information:
From the Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut. This study was supported by grants EY-02365 (Dr. Gregerson) and EY-00785 from the National Institutes of Health and by grants from the Connecticut Lions Eye Research Foundation and Research to Prevent Blindness, Inc.


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