Longitudinal Reinforcement of Acute Myocardial Infarcts Improves Function by Transmurally Redistributing Stretch and Stress

Ana Cristina Estrada, Kyoko Yoshida, Samantha A. Clarke, Jeffrey W. Holmes

Research output: Contribution to journalArticlepeer-review

Abstract

A wide range of emerging therapies, from surgical restraint to biomaterial injection to tissue engineering, aim to improve heart function and limit adverse remodeling following myocardial infarction (MI). We previously showed that longitudinal surgical reinforcement of large anterior infarcts in dogs could significantly enhance systolic function without restricting diastolic function, but the underlying mechanisms for this improvement are poorly understood. The goal of this study was to construct a finite element model that could match our previously published data on changes in regional strains and left ventricular function following longitudinal surgical reinforcement, then use the model to explore potential mechanisms for the improvement in systolic function we observed. The model presented here, implemented in febio, matches all the key features of our experiments, including diastolic remodeling strains in the ischemic region, small shifts in the end-diastolic pressure-volume relationship (EDPVR), and large changes in the end-systolic pressure-volume relationship (ESPVR) in response to ischemia and to patch application. Detailed examination of model strains and stresses suggests that longitudinal reinforcement reduces peak diastolic fiber stretch and systolic fiber stress in the remote myocardium and shifts those peaks away from the endocardial surface by reshaping the left ventricle (LV). These findings could help to guide the development of novel therapies to improve post-MI function by providing specific design objectives.

Original languageEnglish (US)
Article number021009
JournalJournal of biomechanical engineering
Volume142
Issue number2
DOIs
StatePublished - Feb 1 2020
Externally publishedYes

Bibliographical note

Funding Information:
• National Institutes of Health (NIH) (Grant No. U01 HL127654, Funder ID: 10.13039/100000002). • American Heart Association (AHA) (Grant No. 16PRE30250007, Funder ID: 10.13039/100000968).

Publisher Copyright:
© 2020 by ASME.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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