Longitudinal patterns of cortisol regulation differ in maltreated and nonmaltreated children

Jenalee R. Doom, Dante Cicchetti, Fred A. Rogosch

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Objective: Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Specifically, disruptions in hypothalamic-pituitary-adrenal (HPA) axis regulation have been reported in maltreated children. The current study investigates whether increased cortisol variability is responsible for inconsistent patterns in the literature. Method: This study modeled cortisol activity over 20 weeks in 187 maltreated and 154 nonmaltreated children (mean = 8.4 years, SD = 1.8 years) in order to capture week-to-week cortisol patterns. Maltreatment was assessed through coding of Department of Human Services records. Children attended an after-school program 1 day per week for 20 weeks, where saliva was collected at the same time each day and subsequently assayed for cortisol. Results: Multiple-group growth curves indicated that maltreated and nonmaltreated children differ in longitudinal cortisol patterns. Maltreated children showed higher variance in the initial cortisol levels and slope over time compared to nonmaltreated children, indicating greater between-person variability in the maltreated group. Maltreated children with higher cortisol at the first assessment showed cortisol suppression over time, indicating potential HPA blunting after chronic high cortisol levels. The severity, timing, and number of subtypes of maltreatment predicted individuals' cortisol variability, and both maltreatment status and greater cortisol variability predicted more behavior problems. Conclusion: Interventions for maltreated children may benefit from pre- and post-intervention HPA assessments to determine a component of treatment efficacy. As maltreatment dimensions predicted differential cortisol regulation, assessment of maltreatment experiences is necessary to understand alterations in behavior and HPA regulation post-intervention.

Original languageEnglish (US)
Pages (from-to)1206-1215
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume53
Issue number11
DOIs
StatePublished - 2014

Bibliographical note

Funding Information:
Support was provided by grants received from the National Institute of Mental Health (NIMH; 1 R01MH083979-01A1) and the Spunk Fund, Inc., both to D.C. Support for Ms. Doom came from an NIMH training grant (T32MH015755, Principal Investigator: D.C.).

Publisher Copyright:
© 2014 American Academy of Child and Adolescent Psychiatry.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Behavior problems
  • Cortisol
  • Maltreatment
  • Middle childhood
  • Structural equation modeling

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