Longitudinal measures of maternal vitamin D and neonatal body composition

Nansi S. Boghossian; Winston Koo; Aiyi Liu; Sunni L. Mumford; Michael Y. Tsai; Edwina H. Yeung

doi:10.1038/s41430-018-0212-0

Longitudinal measures of maternal vitamin D and neonatal body composition

Nansi S. Boghossian, Winston Koo, Aiyi Liu, Sunni L. Mumford, Michael Y. Tsai, Edwina H. Yeung

Laboratory Medicine and Pathology

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Abstract

BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA).

SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium.

RESULTS: Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm 2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m 3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile.

CONCLUSION: Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.

Original language	English (US)
Pages (from-to)	424-431
Number of pages	8
Journal	European Journal of Clinical Nutrition
Volume	73
Issue number	3
DOIs	https://doi.org/10.1038/s41430-018-0212-0
State	Published - Mar 1 2019

Bibliographical note

Funding Information:
Funding Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The CPEP trial was originally supported by contracts (N01-HD-1-3121, -3122, -3123, -3124, -3125, and -3126; N01-HD-3154; and N01-HD-5-3246) with the National Institute of Child Health and Human Development, with co-funding from the National Heart, Lung, and Blood Institute. Additional biomarker assays including for vitamin D was supported by contract (HHSN275201300023I-HHSN2750002) with the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Publisher Copyright:
© 2018, Macmillan Publishers Limited, part of Springer Nature.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291375

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title = "Longitudinal measures of maternal vitamin D and neonatal body composition",

abstract = "BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA).SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium.RESULTS: Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm 2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m 3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile. CONCLUSION: Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.",

author = "Boghossian, {Nansi S.} and Winston Koo and Aiyi Liu and Mumford, {Sunni L.} and Tsai, {Michael Y.} and Yeung, {Edwina H.}",

note = "Funding Information: Funding Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The CPEP trial was originally supported by contracts (N01-HD-1-3121, -3122, -3123, -3124, -3125, and -3126; N01-HD-3154; and N01-HD-5-3246) with the National Institute of Child Health and Human Development, with co-funding from the National Heart, Lung, and Blood Institute. Additional biomarker assays including for vitamin D was supported by contract (HHSN275201300023I-HHSN2750002) with the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Publisher Copyright: {\textcopyright} 2018, Macmillan Publishers Limited, part of Springer Nature.",

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doi = "10.1038/s41430-018-0212-0",

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T1 - Longitudinal measures of maternal vitamin D and neonatal body composition

AU - Boghossian, Nansi S.

AU - Koo, Winston

AU - Liu, Aiyi

AU - Mumford, Sunni L.

AU - Tsai, Michael Y.

AU - Yeung, Edwina H.

N1 - Funding Information: Funding Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The CPEP trial was originally supported by contracts (N01-HD-1-3121, -3122, -3123, -3124, -3125, and -3126; N01-HD-3154; and N01-HD-5-3246) with the National Institute of Child Health and Human Development, with co-funding from the National Heart, Lung, and Blood Institute. Additional biomarker assays including for vitamin D was supported by contract (HHSN275201300023I-HHSN2750002) with the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Publisher Copyright: © 2018, Macmillan Publishers Limited, part of Springer Nature.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA).SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium.RESULTS: Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm 2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m 3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile. CONCLUSION: Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.

AB - BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA).SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium.RESULTS: Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm 2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m 3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile. CONCLUSION: Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.

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Longitudinal measures of maternal vitamin D and neonatal body composition

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