BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA).
SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium.
RESULTS: Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm 2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m 3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile.
CONCLUSION: Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.
|Original language||English (US)|
|Number of pages||8|
|Journal||European Journal of Clinical Nutrition|
|State||Published - Mar 1 2019|
Bibliographical noteFunding Information:
Funding Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The CPEP trial was originally supported by contracts (N01-HD-1-3121, -3122, -3123, -3124, -3125, and -3126; N01-HD-3154; and N01-HD-5-3246) with the National Institute of Child Health and Human Development, with co-funding from the National Heart, Lung, and Blood Institute. Additional biomarker assays including for vitamin D was supported by contract (HHSN275201300023I-HHSN2750002) with the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
© 2018, Macmillan Publishers Limited, part of Springer Nature.
PubMed: MeSH publication types
- Journal Article