Longer legs are associated with greater risk of incident venous thromboembolism independent of total body height: The longitudinal study of thromboembolism etiology (LITE)

Pamela L. Lutsey, Mary Cushman, Susan R. Heckbert, Weihong Tang, Aaron R. Folsom

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Several studies have reported that taller individuals are at greater risk of venous thromboembolism (VTE). We hypothesised that longer leg length would be positively associated with incident VTE, and would explain the height association. LITE ascertained VTE in a prospective population-based sample of 21,860 individuals aged 45 and older. Leglength was measured as standing height minus torso length. Coxregression models were adjusted for age, race, sex, waist circumference,diabetes, and factor VIII. To evaluate whether leg length was associatedwith VTE risk independent of height, we standardised leg length andheight per 1 standard deviation (SD), and then included them simultaneously in Cox regression models. A total of 641 incident VTE cases accrued over a median follow-up of 16 years. Participants in the highest quintile of leg length were at 59% (95% CI: 22%-108%) greater risk of VTE, relative to the lowest quintile. For height, risk was 45% (12%-88%) greater for those in the highest quintile, compared to the lowest. When leg length and height were modelled simultaneously leg length remained associated with VTE risk (HR per 1 SD: 1.21 (1.04-1.40) while height was unrelated (HR per 1 SD: 1.00 (0.86-1.16).To conclude, participants with longer legs were at greater risk of incident VTE, and leg length explained the relation of height to VTE. It remains to be established whether this finding is due to greater venous surface area, a larger number of venous valves, or greater hydrostatic pressure among individuals with longer legs.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalThrombosis and Haemostasis
Volume106
Issue number1
DOIs
StatePublished - Jul 2011

Keywords

  • Atherosclerosis risk in Communities Study (ARIC), Cardiovascular Health Study (CHS)
  • Height
  • Leg length
  • Venous thromboembolism

Fingerprint Dive into the research topics of 'Longer legs are associated with greater risk of incident venous thromboembolism independent of total body height: The longitudinal study of thromboembolism etiology (LITE)'. Together they form a unique fingerprint.

Cite this