Long-term Survival of Patients with Hodgkin's Disease: Treatment With Cyclophosphamide, Vinblastine, Procarbazine, and Prednisone

Gerald E. Gibbs, Bruce A Peterson, B. J. Kennedy, Gerald Vosika, Clara D. Bloomfield

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thirty-eight patients with advanced Hodgkin's disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP); the minimum period of observation for surviving patients was five years. Twenty-eight patients (74%) achieved complete remission; in 17 (61%), remissions lasted at least five years. Twenty-five (66%) of the 38 patients survived more than five years from the initiation of CVPP. There were no differences in either rates or duration of response when evaluation was performed for multiple pretreatment clinical features. However, survival was adversely influenced by advanced age, nodular sclerosis histologic subtype, and pretreatment bone marrow involvement. Two patients died, in remission, of overwhelming viral infections, and acute nonlymphocytic leukemia developed in one patient. In another patient, aseptic necrosis of the heads of both femora developed. Our data suggest that treatment with CVPP may result in long-term disease-free survival for patients with advanced Hodgkin's disease.

Original languageEnglish (US)
Pages (from-to)897-900
Number of pages4
JournalArchives of Internal Medicine
Volume141
Issue number7
DOIs
StatePublished - Jun 1981

Fingerprint Dive into the research topics of 'Long-term Survival of Patients with Hodgkin's Disease: Treatment With Cyclophosphamide, Vinblastine, Procarbazine, and Prednisone'. Together they form a unique fingerprint.

Cite this