Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Philip R. Fox; Bruce W. Keene; Kenneth Lamb; Karsten E. Schober; Valérie Chetboul; Virginia Luis Fuentes; Jessie Rose Payne; Gerhard Wess; Daniel F. Hogan; Jonathan A. Abbott; Jens Häggström; Geoffrey Culshaw; Deborah Fine-Ferreira; Etienne Cote; Emilie Trehiou-Sechi; Alison A. Motsinger-Reif; Reid K. Nakamura; Manreet Singh; Wendy A. Ware; Sabine C. Riesen; Michele Borgarelli; John E. Rush; Andrea Vollmar; Michael B. Lesser; Nicole Van Israel; Pamela Ming Show Lee; Barret Bulmer; Roberto Santilli; Maribeth J. Bossbaly; Nadine Quick; Claudio Bussadori; Janice Bright; Amara H. Estrada; Dan G. Ohad; Maria Josefa Fernández del Palacio; Jennifer Lunney Brayley; Denise S. Schwartz; Sonya G. Gordon; Seung Woo Jung; Christina M. Bove; Paola G. Brambilla; N. Sydney Moïse; Christopher Stauthammer; Cecilia Quintavalla; Ferenc Manczur; Rebecca L. Stepien; Carmel Mooney; Yong Wei Hung; Remo Lobetti; Alice Tamborini; Mark A. Oyama; Andrey Komolov; Yoko Fujii; Romain Pariaut; Masami Uechi; Victoria Yukie Tachika Ohara

doi:10.1111/jvim.15609

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Philip R. Fox, Bruce W. Keene, Kenneth Lamb, Karsten E. Schober, Valérie Chetboul, Virginia Luis Fuentes, Jessie Rose Payne, Gerhard Wess, Daniel F. Hogan, Jonathan A. Abbott, Jens Häggström, Geoffrey Culshaw, Deborah Fine-Ferreira, Etienne Cote, Emilie Trehiou-Sechi, Alison A. Motsinger-Reif, Reid K. Nakamura, Manreet Singh, Wendy A. Ware, Sabine C. RiesenMichele Borgarelli, John E. Rush, Andrea Vollmar, Michael B. Lesser, Nicole Van Israel, Pamela Ming Show Lee, Barret Bulmer, Roberto Santilli, Maribeth J. Bossbaly, Nadine Quick, Claudio Bussadori, Janice Bright, Amara H. Estrada, Dan G. Ohad, Maria Josefa Fernández del Palacio, Jennifer Lunney Brayley, Denise S. Schwartz, Sonya G. Gordon, Seung Woo Jung, Christina M. Bove, Paola G. Brambilla, N. Sydney Moïse, Christopher Stauthammer, Cecilia Quintavalla, Ferenc Manczur, Rebecca L. Stepien, Carmel Mooney, Yong Wei Hung, Remo Lobetti, Alice Tamborini, Mark A. Oyama, Andrey Komolov, Yoko Fujii, Romain Pariaut, Masami Uechi, Victoria Yukie Tachika Ohara

Veterinary Clinical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines. Objectives: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats. Animals: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries. Methods: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews. Results: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P =.48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P <.001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P =.10), but all-cause survival was significantly shorter in pHCM (P =.0001). Conclusions and Clinical Importance: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.

Original language	English (US)
Pages (from-to)	2572-2586
Number of pages	15
Journal	Journal of veterinary internal medicine
Volume	33
Issue number	6
DOIs	https://doi.org/10.1111/jvim.15609
State	Published - Nov 1 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Keywords

cancer
chronic kidney disease
epidemiology
mortality
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1111/jvim.15609

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Fox, P. R., Keene, B. W., Lamb, K., Schober, K. E., Chetboul, V., Luis Fuentes, V., Payne, J. R., Wess, G., Hogan, D. F., Abbott, J. A., Häggström, J., Culshaw, G., Fine-Ferreira, D., Cote, E., Trehiou-Sechi, E., Motsinger-Reif, A. A., Nakamura, R. K., Singh, M., Ware, W. A., ... Yukie Tachika Ohara, V. (2019). Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy. Journal of veterinary internal medicine, 33(6), 2572-2586. https://doi.org/10.1111/jvim.15609

Fox, PR, Keene, BW, Lamb, K, Schober, KE, Chetboul, V, Luis Fuentes, V, Payne, JR, Wess, G, Hogan, DF, Abbott, JA, Häggström, J, Culshaw, G, Fine-Ferreira, D, Cote, E, Trehiou-Sechi, E, Motsinger-Reif, AA, Nakamura, RK, Singh, M, Ware, WA, Riesen, SC, Borgarelli, M, Rush, JE, Vollmar, A, Lesser, MB, Van Israel, N, Lee, PMS, Bulmer, B, Santilli, R, Bossbaly, MJ, Quick, N, Bussadori, C, Bright, J, Estrada, AH, Ohad, DG, del Palacio, MJF, Brayley, JL, Schwartz, DS, Gordon, SG, Jung, SW, Bove, CM, Brambilla, PG, Moïse, NS, Stauthammer, C, Quintavalla, C, Manczur, F, Stepien, RL, Mooney, C, Hung, YW, Lobetti, R, Tamborini, A, Oyama, MA, Komolov, A, Fujii, Y, Pariaut, R, Uechi, M & Yukie Tachika Ohara, V 2019, 'Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy', Journal of veterinary internal medicine, vol. 33, no. 6, pp. 2572-2586. https://doi.org/10.1111/jvim.15609

@article{5160024fa0d545bbb203186d46abd31f,

title = "Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy",

abstract = "Background: Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines. Objectives: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats. Animals: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries. Methods: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews. Results: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P =.48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P <.001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P =.10), but all-cause survival was significantly shorter in pHCM (P =.0001). Conclusions and Clinical Importance: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.",

keywords = "cancer, chronic kidney disease, epidemiology, mortality, survival",

author = "Fox, {Philip R.} and Keene, {Bruce W.} and Kenneth Lamb and Schober, {Karsten E.} and Val{\'e}rie Chetboul and {Luis Fuentes}, Virginia and Payne, {Jessie Rose} and Gerhard Wess and Hogan, {Daniel F.} and Abbott, {Jonathan A.} and Jens H{\"a}ggstr{\"o}m and Geoffrey Culshaw and Deborah Fine-Ferreira and Etienne Cote and Emilie Trehiou-Sechi and Motsinger-Reif, {Alison A.} and Nakamura, {Reid K.} and Manreet Singh and Ware, {Wendy A.} and Riesen, {Sabine C.} and Michele Borgarelli and Rush, {John E.} and Andrea Vollmar and Lesser, {Michael B.} and {Van Israel}, Nicole and Lee, {Pamela Ming Show} and Barret Bulmer and Roberto Santilli and Bossbaly, {Maribeth J.} and Nadine Quick and Claudio Bussadori and Janice Bright and Estrada, {Amara H.} and Ohad, {Dan G.} and {del Palacio}, {Maria Josefa Fern{\'a}ndez} and Brayley, {Jennifer Lunney} and Schwartz, {Denise S.} and Gordon, {Sonya G.} and Jung, {Seung Woo} and Bove, {Christina M.} and Brambilla, {Paola G.} and Mo{\"i}se, {N. Sydney} and Christopher Stauthammer and Cecilia Quintavalla and Ferenc Manczur and Stepien, {Rebecca L.} and Carmel Mooney and Hung, {Yong Wei} and Remo Lobetti and Alice Tamborini and Oyama, {Mark A.} and Andrey Komolov and Yoko Fujii and Romain Pariaut and Masami Uechi and {Yukie Tachika Ohara}, Victoria",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.",

year = "2019",

month = nov,

day = "1",

doi = "10.1111/jvim.15609",

language = "English (US)",

volume = "33",

pages = "2572--2586",

journal = "Journal of veterinary internal medicine",

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TY - JOUR

T1 - Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

AU - Fox, Philip R.

AU - Keene, Bruce W.

AU - Lamb, Kenneth

AU - Schober, Karsten E.

AU - Chetboul, Valérie

AU - Luis Fuentes, Virginia

AU - Payne, Jessie Rose

AU - Wess, Gerhard

AU - Hogan, Daniel F.

AU - Abbott, Jonathan A.

AU - Häggström, Jens

AU - Culshaw, Geoffrey

AU - Fine-Ferreira, Deborah

AU - Cote, Etienne

AU - Trehiou-Sechi, Emilie

AU - Motsinger-Reif, Alison A.

AU - Nakamura, Reid K.

AU - Singh, Manreet

AU - Ware, Wendy A.

AU - Riesen, Sabine C.

AU - Borgarelli, Michele

AU - Rush, John E.

AU - Vollmar, Andrea

AU - Lesser, Michael B.

AU - Van Israel, Nicole

AU - Lee, Pamela Ming Show

AU - Bulmer, Barret

AU - Santilli, Roberto

AU - Bossbaly, Maribeth J.

AU - Quick, Nadine

AU - Bussadori, Claudio

AU - Bright, Janice

AU - Estrada, Amara H.

AU - Ohad, Dan G.

AU - del Palacio, Maria Josefa Fernández

AU - Brayley, Jennifer Lunney

AU - Schwartz, Denise S.

AU - Gordon, Sonya G.

AU - Jung, Seung Woo

AU - Bove, Christina M.

AU - Brambilla, Paola G.

AU - Moïse, N. Sydney

AU - Stauthammer, Christopher

AU - Quintavalla, Cecilia

AU - Manczur, Ferenc

AU - Stepien, Rebecca L.

AU - Mooney, Carmel

AU - Hung, Yong Wei

AU - Lobetti, Remo

AU - Tamborini, Alice

AU - Oyama, Mark A.

AU - Komolov, Andrey

AU - Fujii, Yoko

AU - Pariaut, Romain

AU - Uechi, Masami

AU - Yukie Tachika Ohara, Victoria

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines. Objectives: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats. Animals: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries. Methods: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews. Results: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P =.48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P <.001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P =.10), but all-cause survival was significantly shorter in pHCM (P =.0001). Conclusions and Clinical Importance: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.

AB - Background: Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines. Objectives: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats. Animals: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries. Methods: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews. Results: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P =.48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P <.001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P =.10), but all-cause survival was significantly shorter in pHCM (P =.0001). Conclusions and Clinical Importance: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.

KW - cancer

KW - chronic kidney disease

KW - epidemiology

KW - mortality

KW - survival

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DO - 10.1111/jvim.15609

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SN - 0891-6640

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EP - 2586

JO - Journal of veterinary internal medicine

JF - Journal of veterinary internal medicine

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ER -

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Abstract

Bibliographical note

Keywords

UN SDGs

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