Long-term human immunodeficiency virus infection in asymptomatic homosexual and bisexual men with normal cd4+ lymphocyte counts: Immunologic and virologie characteristics

Alan R. Lifson, Susan P. Buchbinder, Haynes W. Sheppard, Alison C. Mawle, Judith C. Wilber, Mark Stanley, Clyde E. Hart, Nancy A. Hessol, Scott D. Holmberg

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129 Scopus citations

Abstract

From a prospective cohort study, 24 asymptomatic men were identified who had been antibody positive for human immunodeficiency virus (HIV) for at least 5 years (median = 9.1) with CD4+lymphocyte counts ⩾ 400 cells/mm3. Of these “nonprogressors,” 23 (96%) had evidence of HIV infection by either HIV culture or the polymerase chain reaction (PCR) for HIV DNA, although only 1 (4%) had a positive assay for HIV RNA (by PCR) and no one was positive for p24 antigen. Compared with 24 antibody-negative men and 14 men with AIDS, nonprogressors had higher CD8+ counts and lower natural killer cell activity. Nonprogressors had higher β 32-microglobulin levels than did seronegative controls, suggesting some degree of immune system activation. Compared with men with AIDS, nonprogressors seemed to have a stronger antibody response to six different HIV-related proteins but did not differ significantly in neutralizing antibody or antibody- dependent cellular cytotoxic activity.

Original languageEnglish (US)
Pages (from-to)959-965
Number of pages7
JournalJournal of Infectious Diseases
Volume163
Issue number5
DOIs
StatePublished - May 1991

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